ArticleACS chemical biology2017
Kinetic Isotope Effects and Transition State Structure for Human Phenylethanolamine N-Methyltransferase.
Article in ACS chemical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 12 citations in OpenAlex.
- Structural dynamics of the π-stacking network governing cofactor-substrate cooperativity of SbSOMT methyltransferase.Communications chemistry · 2026Article
- Quantum tunneling in DNA methylation: A computational study using QM/MM and molecular dynamics.Biophysical journal · 2026Article
- Cell-Effective Transition-State Analogue of PhenylethanolamineBiochemistry · 2023Article
- Methyltransferases: Functions and Applications.Chembiochem : a European journal of chemical biology · 2022Review
- Structure-Based Drug Design of Bisubstrate Inhibitors of PhenylethanolamineJournal of medicinal chemistry · 2020Article
- Transition-State Analogues of PhenylethanolamineJournal of the American Chemical Society · 2020Article
- Novel Propargyl-Linked Bisubstrate Analogues as Tight-Binding Inhibitors for NicotinamideJournal of medicinal chemistry · 2019Article
- High-Affinity Alkynyl Bisubstrate Inhibitors of NicotinamideJournal of medicinal chemistry · 2019Article
- Structure-function studies of tetrahydroprotoberberineThe Journal of biological chemistry · 2019Article
- Equatorial Active Site Compaction and Electrostatic Reorganization in Catechol-ACS catalysis · 2019Article
- The Transition-State Structure for Human MAT2A from Isotope Effects.Journal of the American Chemical Society · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Phenylethanolamine N-methyltransferase (PNMT) catalyzes the S-adenosyl-l-methionine (SAM)-dependent conversion of norepinephrine to epinephrine. Epinephrine has been associated with critical processes in humans including the control of respiration and blood pressure. Additionally, PNMT activity has been suggested to play a role in hypertension and Alzheimer's disease. In the current study, labeled SAM substrates were used to measure primary methyl-
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.