ReviewMolecular ecology2017
The on-again, off-again relationship between mitochondrial genomes and species boundaries.
Review in Molecular ecology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
123 citing papers in PubMed.
- Weak but Repeated Patterns of Co-Introgression of Nuclear OXPHOS Genes and Mitochondrial DNA in Iberian Wall Lizards.Genome biology and evolution · 2026Article
- Disruption of mitonuclear coadaptation and compensatory evolution after an extreme dietary shift in carnivorous butterflies.Molecular biology and evolution · 2026Article
- Genome-wide SNVs revealed reticulate evolutionary history of a Eurasian-African songbird radiation (Zoological research · 2026Article
- Causes and consequences of cytonuclear incompatibility in hybrids of flowering plants.Journal of experimental botany · 2026Review
- Coordinated Evolutionary Rates in Oxidative Phosphorylation Complexes of Papilionoid Legumes: Cytonuclear Coevolution and Relaxed Selection.bioRxiv : the preprint server for biology · 2026Article
- Evolution of genome-wide barriers to gene flow during complex speciation in rattlesnakes.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Sensitivity of genome-wide tests for mitonuclear genetic incompatibilities.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Article
- Uncovering evolutionary and phylogenetic relationships in Glyptothorax species through comparative mitochondrial genomics.Journal, genetic engineering & biotechnology · 2026Article
- Evidence for Paternal Mitochondrial DNA Leakage in Diploid Hybrid Fish Lineages.Animals : an open access journal from MDPI · 2026Article
- Genomic and phylogenetic insights for three species of thrips (Thysanoptera: Terebrantia) associated with Colombian avocado.Journal of insect science (Online) · 2026Article
- Diversification in the steppe rat snakePeerJ · 2026Article
- Unidirectional Mitochondrial Introgression Despite Limited Nuclear Admixture in North American Red-Backed Voles,Ecology and evolution · 2025Article
- Abundant Recurrent Mitochondrial Mutations and Widespread Mitonuclear Epistasis in Caenorhabditis elegans.Molecular biology and evolution · 2025Article
- Integrative genomic and machine learning approaches reveal evolutionary signatures in the winged bean mitochondrial genome.BMC plant biology · 2025Article
- Genome Architecture and Speciation in Plants and Animals.Molecular ecology · 2025Review
- The role of cytonuclear interactions to plant adaptation across aProceedings. Biological sciences · 2025Article
- Mito-nuclear discordance reveals introgressive hybridization following vicariance and secondary contact in Iberian scorpions (Buthidae: Buthus).BMC ecology and evolution · 2025Article
- The cytonuclear interactions during grapevine domestication.Journal of integrative plant biology · 2025Article
- Molecular and morphological insights into the taxonomic classification and introduction pathways of Vespa crabro.Scientific reports · 2025Article
- Strong Signatures of Selection on Candidate Genes Underlying Core Speciation Mechanisms in Desert Tortoises.Molecular ecology resources · 2025Article
63 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The study of reproductive isolation and species barriers frequently focuses on mitochondrial genomes and has produced two alternative and almost diametrically opposed narratives. On one hand, mtDNA may be at the forefront of speciation events, with co-evolved mitonuclear interactions responsible for some of the earliest genetic incompatibilities arising among isolated populations. On the other hand, there are numerous cases of introgression of mtDNA across species boundaries even when nuclear gene flow is restricted. We argue that these seemingly contradictory patterns can result from a single underlying cause. Specifically, the accumulation of deleterious mutations in mtDNA creates a problem with two alternative evolutionary solutions. In some cases, compensatory or epistatic changes in the nuclear genome may ameliorate the effects of mitochondrial mutations, thereby establishing coadapted mitonuclear genotypes within populations and forming the basis of reproductive incompatibilities between populations. Alternatively, populations with high mitochondrial mutation loads may be rescued by replacement with a more fit, foreign mitochondrial haplotype. Coupled with many nonadaptive mechanisms of introgression that can preferentially affect cytoplasmic genomes, this form of adaptive introgression may contribute to the widespread discordance between mitochondrial and nuclear genealogies. Here, we review recent advances related to mitochondrial introgression and mitonuclear incompatibilities, including the potential for cointrogression of mtDNA and interacting nuclear genes. We also address an emerging controversy over the classic assumption that selection on mitochondrial genomes is inefficient and discuss the mechanisms that lead lineages down alternative evolutionary paths in response to mitochondrial mutation accumulation.
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