ArticleMolecular ecology2017
Dynamics of Escherichia coli type I-E CRISPR spacers over 42 000 years.
Article in Molecular ecology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- TheEcoSal Plus · 2025Review
- Escherichia coli CRISPR arrays from early life fecal samples preferentially target prophages.The ISME journal · 2024Article
- CRISPR-Cas Controls Cryptic Prophages.International journal of molecular sciences · 2022Article
- Distribution of CRISPR inAnimals : an open access journal from MDPI · 2022Article
- Genetic characterization of third- or fourth-generation cephalosporin-resistant avian pathogenicFrontiers in veterinary science · 2022Article
- Divergent degeneration of creA antitoxin genes from minimal CRISPRs and the convergent strategy of tRNA-sequestering CreT toxins.Nucleic acids research · 2021Article
- Shining light on a deep-sea bacterial symbiont population structure with CRISPR.Microbial genomics · 2021Article
- Pruning and Tending Immune Memories: Spacer Dynamics in the CRISPR Array.Frontiers in microbiology · 2021Review
- Mapping CRISPR spaceromes reveals vast host-specific viromes of prokaryotes.Communications biology · 2020Article
- Virus-borne mini-CRISPR arrays are involved in interviral conflicts.Nature communications · 2019Article
- Long reads reveal the diversification and dynamics of CRISPR reservoir in microbiomes.BMC genomics · 2019Article
- Endogenous Gene Regulation as a Predicted Main Function of Type I-E CRISPR/Cas System inMolecules (Basel, Switzerland) · 2019Article
- Mechanisms of Type I-E and I-F CRISPR-Cas Systems inEcoSal Plus · 2019Review
- A Simple Criterion for Inferring CRISPR Array Direction.Frontiers in microbiology · 2019Article
- Review
- Article
- Article
- Long-term genomic coevolution of host-parasite interaction in the natural environment.Nature communications · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
CRISPR-Cas are nucleic acid-based prokaryotic immune systems. CRISPR arrays accumulate spacers from foreign DNA and provide resistance to mobile genetic elements containing identical or similar sequences. Thus, the set of spacers present in a given bacterium can be regarded as a record of encounters of its ancestors with genetic invaders. Such records should be specific for different lineages and change with time, as earlier acquired spacers get obsolete and are lost. Here, we studied type I-E CRISPR spacers of Escherichia coli from extinct pachyderm. We find that many spacers recovered from intestines of a 42 000-year-old mammoth match spacers of present-day E. coli. Present-day CRISPR arrays can be reconstructed from palaeo sequences, indicating that the order of spacers has also been preserved. The results suggest that E. coli CRISPR arrays were not subject to intensive change through adaptive acquisition during this time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.