Evidence map›Paper›PMID 27996938›Full record

ArticleeLife2016

CCR5 is a suppressor for cortical plasticity and hippocampal learning and memory.

Miou Zhou, Stuart Greenhill, Shan Huang, Tawnie K Silva, Yoshitake Sano, Shumin Wu, Ying Cai, Yoshiko Nagaoka, Megha Sehgal, Denise J Cai and 3 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04789616 (The CAMAROS Trial), which is not on this map. Cited by 90 papers.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04789616 phase2unknown statusnot on this mapstarted 2022, after this paper: background citation

The CAMAROS Trial: The Canadian Maraviroc Randomized Controlled Trial To Augment Rehabilitation Outcomes After Stroke

TypeinterventionalSponsorUniversity of CalgaryRan2022 to 2025Enrolled120ConditionsStrokeArmsMaraviroc, Exercise Program, Placebo, Activity Sensor, Motor Learning
3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 169 citations in OpenAlex.

  1. Trial
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  4. Article
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  10. IL-1ra and CCL5, but not IL-10, are promising targets for treating SMA astrocyte-driven pathology.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  11. 5-HTJournal of advanced research · 2025
    Article
  12. Review
  13. Article
  14. The contributing role of CCR5 in dementia.Frontiers in neurology · 2025
    Review
  15. Article
  16. Article
  17. Article
  18. Intrinsic Neural Excitability Biases Allocation and Overlap of Memory Engrams.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  19. Article
  20. Review

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 4 countries.

Miou ZhouDepartments of Neurobiology, Psychology, Psychiatry, Integrative Center for Learning and Memory and Brain Research Institute, University of California, Los Angeles, Los Angeles, United States.
Stuart GreenhillCardiff School of Biosciences, Cardiff University, Cardiff, United Kingdom.ORCID 0000-0002-5038-5258
Shan HuangDepartments of Neurobiology, Psychology, Psychiatry, Integrative Center for Learning and Memory and Brain Research Institute, University of California, Los Angeles, Los Angeles, United States.
Tawnie K SilvaDepartments of Neurobiology, Psychology, Psychiatry, Integrative Center for Learning and Memory and Brain Research Institute, University of California, Los Angeles, Los Angeles, United States.
Yoshitake SanoDepartments of Neurobiology, Psychology, Psychiatry, Integrative Center for Learning and Memory and Brain Research Institute, University of California, Los Angeles, Los Angeles, United States.
Shumin WuDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, United States.
Ying CaiDepartments of Neurobiology, Psychology, Psychiatry, Integrative Center for Learning and Memory and Brain Research Institute, University of California, Los Angeles, Los Angeles, United States.
Yoshiko NagaokaDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, United States.
Megha SehgalDepartments of Neurobiology, Psychology, Psychiatry, Integrative Center for Learning and Memory and Brain Research Institute, University of California, Los Angeles, Los Angeles, United States.
Denise J CaiDepartments of Neurobiology, Psychology, Psychiatry, Integrative Center for Learning and Memory and Brain Research Institute, University of California, Los Angeles, Los Angeles, United States.
Yong-Seok LeeDepartments of Neurobiology, Psychology, Psychiatry, Integrative Center for Learning and Memory and Brain Research Institute, University of California, Los Angeles, Los Angeles, United States.
Kevin FoxCardiff School of Biosciences, Cardiff University, Cardiff, United Kingdom.
Alcino J SilvaDepartments of Neurobiology, Psychology, Psychiatry, Integrative Center for Learning and Memory and Brain Research Institute, University of California, Los Angeles, Los Angeles, United States.ORCID 0000-0002-1587-4558
University of California, Los Angeles · USAston University · GBCardiff University · GBSeoul National University · KRTokyo University of Science · JP

Funding

Variation as a Neural CodeP50MH077970 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BRAINARD, MICHAEL S · 2006 to 2010
$9.6M
UCLA Center for Translational Research in Neurodevelopment: UC-TRaNU54HD087101 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MCCRACKEN, JAMES T. · 2016 to 2020
$6.5M
Medical Research Council G0901299Medical Research Council MR/N003896/1NICHD NIH HHS U54 HD087101NIMH NIH HHS P50 MH077970
6 · The paper itself

Abstract

Although the role of CCR5 in immunity and in HIV infection has been studied widely, its role in neuronal plasticity, learning and memory is not understood. Here, we report that decreasing the function of CCR5 increases MAPK/CREB signaling, long-term potentiation (LTP), and hippocampus-dependent memory in mice, while neuronal CCR5 overexpression caused memory deficits. Decreasing CCR5 function in mouse barrel cortex also resulted in enhanced spike timing dependent plasticity and consequently, dramatically accelerated experience-dependent plasticity. These results suggest that CCR5 is a powerful suppressor for plasticity and memory, and CCR5 over-activation by viral proteins may contribute to HIV-associated cognitive deficits. Consistent with this hypothesis, the HIV V3 peptide caused LTP, signaling and memory deficits that were prevented by Ccr5 knockout or knockdown. Overall, our results demonstrate that CCR5 plays an important role in neuroplasticity, learning and memory, and indicate that CCR5 has a role in the cognitive deficits caused by HIV.

Indexed as

LearningMemoryNeuronal PlasticityAction PotentialsAnimalsCerebral CortexHippocampusMiceNeuronsReceptors, CCR5CCR5 protein, mouseReceptors, CCR5barrel cortexCCR5gp120hippocampusHIV-associated cognitive deficitslearning and memorymouseneuroscience

Identifiers

PMID27996938
PMCPMC5213777
OpenAlexW2561607968

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.