ArticleThe American journal of bioethics : AJOB2017
A Framework for Unrestricted Prenatal Whole-Genome Sequencing: Respecting and Enhancing the Autonomy of Prospective Parents.
Article in The American journal of bioethics : AJOB, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Rethinking the Burden of Traditional Informed Consent Prior to Prenatal Genetic Screening.The Hastings Center report · 2025Article
- Healthcare professionals' experiences with expanded noninvasive prenatal screening: challenges and solutions.Journal of community genetics · 2025Article
- Polygenic embryo screening: quo vadis?Journal of assisted reproduction and genetics · 2024Review
- Patient interest in and clinician reservations on polygenic embryo screening: a qualitative study of stakeholder perspectives.Journal of assisted reproduction and genetics · 2024Article
- Factors affecting couples' decision making about expanded prenatal cell-free DNA screening.Genetics in medicine open · 2024Article
- Divergence Between Clinician and Patient Perspectives on Polygenic Embryo Screening: A Qualitative Study.medRxiv : the preprint server for health sciences · 2023Article
- An autonomy-based approach to assisted suicide: a way to avoid the expressivist objection against assisted dying laws.Journal of medical ethics · 2023Article
- Non-Invasive Prenatal Testing for "Non-Medical" Traits: Ensuring Consistency in Ethical Decision-Making.The American journal of bioethics : AJOB · 2023Article
- Perceived Value of Prenatal Ultrasound Screening: A Survey of Pregnant Women.Maternal and child health journal · 2023Article
- Views of Canadian healthcare professionals on the future uses of non-invasive prenatal testing: a mixed method study.European journal of human genetics : EJHG · 2022Article
- Concerns about the use of polygenic embryo screening for psychiatric and cognitive traits.The lancet. Psychiatry · 2022Review
- The fetus in the age of the genome.Human genetics · 2022Article
- Implementing Expanded Prenatal Genetic Testing: Should Parents Have Access to Any and All Fetal Genetic Information?The American journal of bioethics : AJOB · 2022Article
- Genetic Testing Is Messier in Practice than in Theory: Lessons from Neonatology.The American journal of bioethics : AJOB · 2022Article
- Genetic Counseling and Genome Sequencing in Pediatric Rare Disease.Cold Spring Harbor perspectives in medicine · 2020Review
- Just choice: a Danielsian analysis of the aims and scope of prenatal screening for fetal abnormalities.Medicine, health care, and philosophy · 2019Article
- The evolving landscape of expanded carrier screening: challenges and opportunities.Genetics in medicine : official journal of the American College of Medical Genetics · 2019Review
- Ethics in genetic counselling.Journal of community genetics · 2019Review
- Knowledge Gaps and Emerging Research Areas in Intrauterine Growth Restriction-Associated Brain Injury.Frontiers in endocrinology · 2019Review
- Ethical and counseling challenges in prenatal exome sequencing.Prenatal diagnosis · 2018Article
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
- Commented on by
- Commented on by
- Commented on by
- Commented on by
- Commented on by
- Commented on by
- Commented on by
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Noninvasive, prenatal whole genome sequencing (NIPW) may be a technological reality in the near future, making available a vast array of genetic information early in pregnancy at no risk to the fetus or mother. Many worry that the timing, safety, and ease of the test will lead to informational overload and reproductive consumerism. The prevailing response among commentators has been to restrict conditions eligible for testing based on medical severity, which imposes disputed value judgments and devalues those living with eligible conditions. To avoid these difficulties, we propose an unrestricted testing policy, under which prospective parents could obtain information on any variant of known significance after a careful informed consent process that uses an interactive decision aid to deliver a mandatory presentation on the purposes, techniques, and limitations of genomic testing, as well as optional resources for reflection and consultation. This process would encourage thoughtful, informed deliberation by prospective parents before deciding whether or how to use NIPW.
Indexed as
Identifiers
27996923What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.