ArticleScientific reports2016
Compound to Extract to Formulation: a knowledge-transmitting approach for metabolites identification of Gegen-Qinlian Decoction, a traditional Chinese medicine formula.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- An Efficacy- and In Vivo Exposure-Oriented Integrated Study to Investigate the Effective Components ofPharmaceuticals (Basel, Switzerland) · 2025Article
- The protective effect of naringenin on ulcerative colitis in mice through increasing Nrf2 pathway activity.Acta biochimica et biophysica Sinica · 2025Article
- Protective Application of Chinese Herbal Compounds and Formulae in Intestinal Inflammation in Humans and Animals.Molecules (Basel, Switzerland) · 2023Review
- Gegen Qinlian Decoction treatment of asymptomatic hyperuricemia by targeting circadian immune function.Chinese medicine · 2023Article
- Focal Microscopy Observe the Mechanism of Gegen Qinlian Decoction Treating Type 2 Diabetic Nephropathy in Nude Mice.BioMed research international · 2022Article
- Using Porcine Jejunum Ex Vivo to Study Absorption and Biotransformation of Natural Products in Plant Extracts:Metabolites · 2021Article
- Network Pharmacology-Based Analysis and Experimental Exploration of Antidiabetic Mechanisms of Gegen Qinlian Decoction.Frontiers in pharmacology · 2021Article
- Constituents, Pharmacokinetics, and Pharmacology ofFrontiers in pharmacology · 2021Review
- In Silico and In Vivo Studies on the Mechanisms of Chinese Medicine Formula (Gegen Qinlian Decoction) in the Treatment of Ulcerative Colitis.Frontiers in pharmacology · 2021Article
- Metabolism of Rhizoma coptidis in Human Urine by Ultra-High-Performance Liquid Chromatography Coupled with High-Resolution Mass Spectrometry.European journal of drug metabolism and pharmacokinetics · 2018Article
- Gut Microbiota, Short-Chain Fatty Acids, and Herbal Medicines.Frontiers in pharmacology · 2018Review
- Comparing the antidiabetic effects and chemical profiles of raw and fermented Chinese Ge-Gen-Qin-Lian decoction by integrating untargeted metabolomics and targeted analysis.Chinese medicine · 2018Article
- A 42-Markers Pharmacokinetic Study Reveals Interactions of Berberine and Glycyrrhizic Acid in the Anti-diabetic Chinese Medicine Formula Gegen-Qinlian Decoction.Frontiers in pharmacology · 2018Article
- Anticancer effect of fufang yiliu yin on human hepatocellular carcinoma SMMC-7721 cells.American journal of translational research · 2018Article
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8 authors.
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Abstract
Herbal medicines usually contain a large group of chemical components, which may be transformed into more complex metabolites in vivo. In this study, we proposed a knowledge-transmitting strategy for metabolites identification of compound formulas. Gegen-Qinlian Decoction (GQD) is a classical formula in traditional Chinese medicine (TCM). It is widely used to treat diarrhea and diabetes in clinical practice. However, only tens of metabolites could be detected using conventional approaches. To comprehensively identify the metabolites of GQD, a "compound to extract to formulation" strategy was established in this study. The metabolic pathways of single representative constituents in GQD were studied, and the metabolic rules were transmitted to chemically similar compounds in herbal extracts. After screening diversified metabolites from herb extracts, the knowledge was summarized to identify the metabolites of GQD. Tandem mass spectrometry (MS
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