ArticleScientific reports2016
Mild intrauterine hypoperfusion reproduces neurodevelopmental disorders observed in prematurity.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Intravenous administration of ex vivo expanded human umbilical cord blood-derived CD34⁺ cells in a preterm hypoxic-ischemic encephalopathy mouse model.Scientific reports · 2026Article
- Modeling cerebral palsy in animals.Developmental medicine and child neurology · 2026Review
- Biomarkers for early detection and monitoring of abnormal brain development in mild fetal growth restriction.iScience · 2025Article
- Enduring effects of acute prenatal ischemia in rat soleus muscle, and protective role of erythropoietin.Journal of muscle research and cell motility · 2025Article
- Comparative Analysis of the Effects of Maternal Hypoxia and Placental Ischemia on HIF1-Dependent Metabolism and the Glucocorticoid System in the Embryonic and Newborn Rat Brain.International journal of molecular sciences · 2024Article
- Early movement restriction impairs the development of sensorimotor integration, motor skills and memory in rats: Towards a preclinical model of developmental coordination disorder?The European journal of neuroscience · 2024Article
- Various Organ Damages in Rats with Fetal Growth Restriction and Their Slight Attenuation byLife (Basel, Switzerland) · 2023Article
- Umbilical cord-derived mesenchymal stromal cell therapy to prevent the development of neurodevelopmental disorders related to low birth weight.Scientific reports · 2023Article
- MIUH Inhibits the Hippocampal Neuron Growth in Fetal Rat by Affecting the PTEN Pathway.Neurochemical research · 2021Article
- Current Therapies for Neonatal Hypoxic-Ischaemic and Infection-Sensitised Hypoxic-Ischaemic Brain Damage.Frontiers in synaptic neuroscience · 2021Review
- Effects of mild intrauterine hypoperfusion in the second trimester on memory and learning function in rat offspring.Neural regeneration research · 2020Article
- Establishment of a Novel Fetal Growth Restriction Model and Development of a Stem-Cell Therapy Using Umbilical Cord-Derived Mesenchymal Stromal Cells.Frontiers in cellular neuroscience · 2020Article
- Cilostazol, a Phosphodiesterase 3 Inhibitor, Moderately Attenuates Behaviors Depending on Sex in the Ts65Dn Mouse Model of Down Syndrome.Frontiers in aging neuroscience · 2020Article
- Tadalafil treatment in mice for preeclampsia with fetal growth restriction has neuro-benefic effects in offspring through modulating prenatal hypoxic conditions.Scientific reports · 2019Article
- Glutamate Transport and Preterm Brain Injury.Frontiers in physiology · 2019Review
- A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis.Journal of visualized experiments : JoVE · 2018Article
- Mild Intrauterine Hypoperfusion Leads to Lumbar and Cortical Hyperexcitability, Spasticity, and Muscle Dysfunctions in Rats: Implications for Prematurity.Frontiers in neurology · 2018Article
- The extent of intrauterine growth restriction determines the severity of cerebral injury and neurobehavioural deficits in rodents.PloS one · 2017Article
- Immunoreactivity of MAPK Signaling in a Rat Model of Intrauterine Growth Retardation Induced by Uterine Artery Ligation.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe intrauterine ischemia is detrimental to the developing brain. The impact of mild intrauterine hypoperfusion on neurological development, however, is still unclear. We induced mild intrauterine hypoperfusion in rats on embryonic day 17 via arterial stenosis with metal microcoils wrapped around the uterine and ovarian arteries. All pups were born with significantly decreased birth weights. Decreased gray and white matter areas were observed without obvious tissue damage. Pups presented delayed newborn reflexes, muscle weakness, and altered spontaneous activity. The levels of proteins indicative of inflammation and stress in the vasculature, i.e., RANTES, vWF, VEGF, and adiponectin, were upregulated in the placenta. The levels of mRNA for proteins associated with axon and astrocyte development were downregulated in fetal brains. The present study demonstrates that even mild intrauterine hypoperfusion can alter neurological development, which mimics the clinical signs and symptoms of children with neurodevelopmental disorders born prematurely or with intrauterine growth restriction.
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