ArticleScientific reports2016
Naa50/San-dependent N-terminal acetylation of Scc1 is potentially important for sister chromatid cohesion.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Metabolic regulation of proteome stability via N-terminal acetylation controls male germline stem cell differentiation and reproduction.Nature communications · 2023Article
- A dual-function SNF2 protein drives chromatid resolution and nascent transcripts removal in mitosis.EMBO reports · 2023Article
- Characterisation and preliminary functional analysis of N-acetyltransferase 13 from Schistosoma japonicum.BMC veterinary research · 2021Article
- A Structure-Based Mechanism for DNA Entry into the Cohesin Ring.Molecular cell · 2020Article
- NAA50 Is an Enzymatically ActivePlant physiology · 2020Article
- Comprehensive genetic analysis of 57 families with clinically suspected Cornelia de Lange syndrome.Journal of human genetics · 2019Article
- Structure and Mechanism of Acetylation by the N-Terminal Dual Enzyme NatA/Naa50 Complex.Structure (London, England : 1993) · 2019Article
- Absence of the Spindle Assembly Checkpoint Restores Mitotic Fidelity upon Loss of Sister Chromatid Cohesion.Current biology : CB · 2018Article
- The Trithorax group protein dMLL3/4 instructs the assembly of the zygotic genome at fertilization.EMBO reports · 2018Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
The gene separation anxiety (san) encodes Naa50/San, a N-terminal acetyltransferase required for chromosome segregation during mitosis. Although highly conserved among higher eukaryotes, the mitotic function of this enzyme is still poorly understood. Naa50/San was originally proposed to be required for centromeric sister chromatid cohesion in Drosophila and human cells, yet, more recently, it was also suggested to be a negative regulator of microtubule polymerization through internal acetylation of beta Tubulin. We used genetic and biochemical approaches to clarify the function of Naa50/San during development. Our work suggests that Naa50/San is required during tissue proliferation for the correct interaction between the cohesin subunits Scc1 and Smc3. Our results also suggest a working model where Naa50/San N-terminally acetylates the nascent Scc1 polypeptide, and that this co-translational modification is subsequently required for the establishment and/or maintenance of sister chromatid cohesion.
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Registered trials
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