ArticleScientific reports2016
A Biomimetic Silk Fibroin/Sodium Alginate Composite Scaffold for Soft Tissue Engineering.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Comprehensive Characterization of Solution-Cast Polycaprolactone/MXene/Gelatin Composite Films for Biomedical Applications.Biopolymers · 2026Article
- Biodegradable Gelatin-Carrageenan Sponges: High-Potential Functional Nasal Packs for Efficient Secretome Delivery.Polymers · 2024Article
- Review
- Development of an alginate-chitosan biopolymer composite with dECM bioink additive for organ-on-a-chip articular cartilage.Scientific reports · 2024Article
- A sodium alginate - silk fibroin biosponge loaded with thrombin: Effective hemostasis and wound healing.Heliyon · 2024Article
- Wound Microenvironment Self-Adjusting Hydrogels with Thermo-Sensitivity for Promoting Diabetic Wound Healing.Gels (Basel, Switzerland) · 2023Article
- Versatile Potential of Photo-Cross-Linkable Silk Fibroin: Roadmap from Chemical Processing Toward Regenerative Medicine and Biofabrication Applications.Biomacromolecules · 2023Review
- Effect of degumming degree on the structure and tensile properties of RSF/RSS composite films prepared by one-step extraction.Scientific reports · 2023Article
- Article
- 3D-Printing of Silk Nanofibrils Reinforced Alginate for Soft Tissue Engineering.Pharmaceutics · 2023Article
- Bio-functional hydrogel with antibacterial and anti-inflammatory dual properties to combat with burn wound infection.Bioengineering & translational medicine · 2023Article
- Impact of a Novel Hydrogel with Injectable Platelet-Rich Fibrin in Diabetic Wound Healing.Journal of diabetes research · 2023Article
- Human epidermal keratinocytes and human dermal fibroblasts interactions seeded on gelatin hydrogel for future application in skinFrontiers in bioengineering and biotechnology · 2023Article
- A Brief Evaluation of Antioxidants, Antistatics, and Plasticizers Additives from Natural Sources for Polymers Formulation.Polymers · 2022Review
- Silk fibroin hydrogels for biomedical applications.Smart medicine · 2022Review
- Advances in spray products for skin regeneration.Bioactive materials · 2022Review
- A smart magnetic hydrogel containing exosome promotes osteogenic commitment of human adipose-derived mesenchymal stem cells.Iranian journal of basic medical sciences · 2022Article
- Evaluation of calcium phosphate-coated polycaprolactone/graphene oxide scaffold with macro- and microporous structure for bone tissue engineering.In vitro models · 2022Article
- Liquid-type plasma-controlled in situ crosslinking of silk-alginate injectable gel displayed better bioactivities and mechanical properties.Materials today. Bio · 2022Article
- Electrospun Silk Fibroin/Biology · 2022Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A cytocompatible porous scaffold mimicking the properties of extracellular matrices (ECMs) has great potential in promoting cellular attachment and proliferation for tissue regeneration. A biomimetic scaffold was prepared using silk fibroin (SF)/sodium alginate (SA) in which regular and uniform pore morphology can be formed through a facile freeze-dried method. The scanning electron microscopy (SEM) studies showed the presence of interconnected pores, mostly spread over the entire scaffold with pore diameter around 54~532 μm and porosity 66~94%. With significantly better water stability and high swelling ratios, the blend scaffolds crosslinked by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) provided sufficient time for the formation of neo-tissue and ECMs during tissue regeneration. Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) results confirmed random coil structure and silk I conformation were maintained in the blend scaffolds. What's more, FI-TR spectra demonstrated crosslinking reactions occurred actually among EDC, SF and SA macromolecules, which kept integrity of the scaffolds under physiological environment. The suitable pore structure and improved equilibrium swelling capacity of this scaffold could imitate biochemical cues of natural skin ECMs for guiding spatial organization and proliferation of cells in vitro, indicating its potential candidate material for soft tissue engineering.
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