Evidence map›Paper›PMID 27995986›Full record

ArticleScientific reports2016

Persistent p55TNFR expression impairs T cell responses during chronic tuberculosis and promotes reactivation.

Ivy M Dambuza, Roanne Keeton, Nai-Jen Hsu, Nasiema Allie, Valérie F J Quesniaux, Bernhard Ryffel, Muazzam Jacobs

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Ivy M DambuzaDivision of Immunology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa.
Roanne KeetonDivision of Immunology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa.
Nai-Jen HsuDivision of Immunology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa.
Nasiema AllieDivision of Immunology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa.
Valérie F J QuesniauxCNRS UMR7355, Experimental and Molecular Immunology and Neurogenetics, 45071 Orleans, France.
Bernhard RyffelCNRS UMR7355, Experimental and Molecular Immunology and Neurogenetics, 45071 Orleans, France.
Muazzam JacobsDivision of Immunology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa.
University of Cape Town · ZACentre National de la Recherche Scientifique · FRNational Health Laboratory Service · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pleiotropic activities of TNF are mediated by two structurally related but functionally distinct type I transmembrane receptors, p55TNFR and p75TNFR expressed in most cell types, that can be cleaved and act as TNF scavengers. Here, we investigated the effect of persistent p55TNFR cell surface expression during aerosol inhalation challenge with virulent M. tuberculosis H37Rv. We demonstrated that persistency of p55TNFR in macrophage cultures increased the synthesis of soluble TNF, p75TNFR and NO, however, had no effects on bacteria killing ability. Furthermore, it did not facilitate enhanced protection to primary acute M. tuberculosis infection in p55

Indexed as

AnimalsChronic DiseaseCytokinesEnzyme-Linked Immunosorbent AssayHyaluronan ReceptorsInterferon-gammaLatent TuberculosisLungMacrophages, PeritonealMiceMice, Inbred C57BLMycobacterium tuberculosisNitric OxideReceptors, Tumor Necrosis Factor, Type IT-LymphocytesCd44 protein, mouseCytokinesHyaluronan ReceptorsInterferon-gammaNitric OxideReceptors, Tumor Necrosis Factor, Type ITnfrsf1a protein, mouse

Identifiers

PMID27995986
PMCPMC5171238
OpenAlexW2565651301

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.