Evidence map›Paper›PMID 27995969›Full record

ArticleScientific reports2016

Biliary Phospholipids Sustain Enterocyte Proliferation and Intestinal Tumor Progression via Nuclear Receptor Lrh1 in mice.

Michele Petruzzelli, Elena Piccinin, Claudio Pinto, Claudia Peres, Elena Bellafante, Antonio Moschetta

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Inactivation of Group 1B Phospholipase AInternational journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Michele PetruzzelliDepartment of Interdisciplinary Medicine, "Aldo Moro" University of Bari, 70124 Bari, Italy.
Elena PiccininDepartment of Interdisciplinary Medicine, "Aldo Moro" University of Bari, 70124 Bari, Italy.
Claudio PintoFondazione Mario Negri Sud, Santa Maria Imbaro, 66030 Chieti, Italy.
Claudia PeresDepartment of Interdisciplinary Medicine, "Aldo Moro" University of Bari, 70124 Bari, Italy.
Elena BellafanteFondazione Mario Negri Sud, Santa Maria Imbaro, 66030 Chieti, Italy.
Antonio MoschettaDepartment of Interdisciplinary Medicine, "Aldo Moro" University of Bari, 70124 Bari, Italy.
University of Bari Aldo Moro · ITMario Negri Sud Foundation · ITIstituti di Ricovero e Cura a Carattere Scientifico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The proliferative-crypt compartment of the intestinal epithelium is enriched in phospholipids and accumulation of phospholipids has been described in colorectal tumors. Here we hypothesize that biliary phospholipid flow could directly contribute to the proliferative power of normal and dysplastic enterocytes. We used Abcb4

Indexed as

AnimalsATP-Binding Cassette Sub-Family B Member 4ATP Binding Cassette Transporter, Subfamily BBiliary TractCarcinogenesisCell ProliferationCyclin D1EnterocytesIntestinal MucosaIntestinal NeoplasmsMaleMiceMice, KnockoutPhospholipidsProliferating Cell Nuclear AntigenReceptors, Cytoplasmic and NuclearATP-Binding Cassette Sub-Family B Member 4ATP Binding Cassette Transporter, Subfamily BCcnd1 protein, mouseCyclin D1Nr5a2 protein, mousePhospholipidsProliferating Cell Nuclear AntigenReceptors, Cytoplasmic and Nuclear

Identifiers

PMID27995969
PMCPMC5171812
OpenAlexW2563392484

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.