ArticleOrganic letters2017
pH-Dependent Fluorescent Probe That Can Be Tuned for Cysteine or Homocysteine.
Article in Organic letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Sensor with Strong Solid Emission for Fluorescence Colormetric Detection of 1, 4-Dioxane in Water and Vapor Based on the Keto-Enol Isomerisation.Journal of fluorescence · 2025Article
- A new GFP chromophore analogue for detection of viscosity and cysteine with AND logic-gate-based fluorescence readout.Analytical and bioanalytical chemistry · 2025Article
- Highly electroactive thiazolium [5,4-d]thiazol-2,5-dicarboxylic acid-silver electrochemiluminescent metal-organic frameworks: synthesis, properties and application in glutathione detection.Mikrochimica acta · 2025Article
- A lysosome-targeted fluorescent probe with large Stokes shift for visualizing biothiolsiScience · 2024Article
- Applications of Pyrrole and Pyridine-based Heterocycles in Cancer Diagnosis and Treatment.Current pharmaceutical design · 2024Review
- Fluorescent Probes for Live Cell Thiol Detection.Molecules (Basel, Switzerland) · 2021Review
- BODIPY-HgAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2021Article
- The chronological evolution of small organic molecular fluorescent probes for thiols.Chemical science · 2020Review
- A near-infrared excitation/emission fluorescent probe for imaging of endogenous cysteine in living cells and zebrafish.Analytical and bioanalytical chemistry · 2020Article
- A Simple Long-wavelength Fluorescent Probe for Simultaneous Discrimination of Cysteine/Homocysteine and Glutathione/Hydrogen Sulfide with Two Separated Fluorescence Emission Channels by Single Wavelength Excitation.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2020Article
- Photoluminescence and Electrochemiluminescence Dual-Signaling Sensors for Selective Detection of Cysteine Based on Iridium(III) Complexes.ACS omega · 2019Article
- A Near-Infrared Ratiometric Fluorescent Probe for Highly Selective Recognition and Bioimaging of Cysteine.Frontiers in chemistry · 2019Article
- Sensing Performance and Efficiency of Two Energy Transfer-Based Two-Photon Fluorescent Probes for pH.Sensors (Basel, Switzerland) · 2018Article
- Fluorescent Probes with Multiple Binding Sites for the Discrimination of Cys, Hcy, and GSH.Angewandte Chemie (International ed. in English) · 2017Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The very close structural similarities between cysteine and homocysteine present a great challenge to achieve their selective detection using regular fluorescent probes, limiting the biological and pathological studies of these two amino thiols. A coumarin-based fluorescent probe was designed featuring pH-promoted distinct turn-on followed by ratiometric fluorescence responses for Cys and turn-on fluorescence response for Hcy through two different reaction paths. These specific responses demonstrate the activity differences between Cys and Hcy qualitatively for the first time. The probe could also be used for Cys and Hcy imaging in living cells.
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Registered trials
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