Evidence map›Paper›PMID 27995755›Full record

ReviewMolecular nutrition & food research2017

Application of phage peptide display technology for the study of food allergen epitopes.

Xueni Chen, Stephen C Dreskin

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular nutrition & food research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Can alternative epitope mapping approaches increase the impact of B-cell epitopes in food allergy diagnostics?Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019
    Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Xueni ChenDivision of Allergy and Clinical Immunology, Departments of Medicine and Immunology, University of Colorado Denver, Aurora, CO, USA.
Stephen C DreskinDivision of Allergy and Clinical Immunology, Departments of Medicine and Immunology, University of Colorado Denver, Aurora, CO, USA.

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025780 · NCRR · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2008 to 2011
$61.3M
Mapping the Critical Epitopes of Ara h 2 and Ara h 6R01AI099029 · NIAID · UNIVERSITY OF COLORADO DENVER · PI DRESKIN, STEPHEN C · 2012 to 2015
$1.5M
Elucidation of conformational epitopes of peanut allergens essential for allergic reactionsR21AI112792 · NIAID · UNIVERSITY OF COLORADO DENVER · PI CHEN, XUENI · 2015 to 2016
$428k
NCRR NIH HHS UL1 RR025780NIAID NIH HHS R01 AI099029NIAID NIH HHS R21 AI112792
6 · The paper itself

Abstract

Phage peptide display technology has been used to identify IgE-binding mimotopes (mimics of natural epitopes) that mimic conformational epitopes. This approach is effective in the characterization of those epitopes that are important for eliciting IgE-mediated allergic responses by food allergens and those that are responsible for cross-reactivity among allergenic food proteins. Application of this technology will increase our understanding of the mechanisms whereby food allergens elicit allergic reactions, will facilitate the discovery of diagnostic reagents and may lead to mimotope-based immunotherapy.

Indexed as

Peptide LibraryAllergensAntigens, PlantBacteriophagesCross ReactionsEpitopesFood HypersensitivityHumansImmunoglobulin EMolecular MimicryAllergensAntigens, PlantEpitopesImmunoglobulin EPeptide LibraryConformational epitopeFood allergyIgE epitopeMimotopesPhage peptide display

Identifiers

PMID27995755
PMCPMC5525323

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.