Evidence map›Paper›PMID 27995690›Full record

ArticleBipolar disorders2016

An investigation of mental imagery in bipolar disorder: Exploring "the mind's eye".

Martina Di Simplicio, Fritz Renner, Simon E Blackwell, Heather Mitchell, Hannah J Stratford, Peter Watson, Nick Myers, Anna C Nobre, Alex Lau-Zhu, Emily A Holmes

Open access · hybridAbstract read
In one paragraph

Article in Bipolar disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.

  1. Pooled it
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  13. Social Anxiety and Mental Imagery Processes.Clinical neuropsychiatry · 2019
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  19. Treatment of Intrusive Suicidal Imagery Using Eye Movements.International journal of environmental research and public health · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Martina Di SimplicioMedical Research Council Cognition and Brain Sciences Unit, Cambridge, UK.ORCID 0000-0001-5701-9659
Fritz RennerMedical Research Council Cognition and Brain Sciences Unit, Cambridge, UK.
Simon E BlackwellMedical Research Council Cognition and Brain Sciences Unit, Cambridge, UK.
Heather MitchellMedical Research Council Cognition and Brain Sciences Unit, Cambridge, UK.
Hannah J StratfordHighfield Inpatient Adolescent Unit, Warneford Hospital, Oxford, UK.
Peter WatsonMedical Research Council Cognition and Brain Sciences Unit, Cambridge, UK.
Nick MyersOxford Centre for Human Brain Activity (OHBA), University of Oxford, Oxford, UK.
Anna C NobreOxford Centre for Human Brain Activity (OHBA), University of Oxford, Oxford, UK.
Alex Lau-ZhuMedical Research Council Cognition and Brain Sciences Unit, Cambridge, UK.
Emily A HolmesMedical Research Council Cognition and Brain Sciences Unit, Cambridge, UK.
MRC Cognition and Brain Sciences Unit · GBUniversity of Oxford · GBWarneford Hospital · GB

Funding

Medical Research Council MC-A060-5PR50Wellcome TrustWellcome Trust WT088217
6 · The paper itself

Abstract

objectivesMental imagery abnormalities occur across psychopathologies and are hypothesized to drive emotional difficulties in bipolar disorder (BD). A comprehensive assessment of mental imagery in BD is lacking. We aimed to test whether (i) mental imagery abnormalities (abnormalities in cognitive stages and subjective domains) occur in BD relative to non-clinical controls; and (ii) to determine the specificity of any abnormalities in BD relative to depression and anxiety disorders.

methodsParticipants included 54 subjects in the BD group (depressed/euthymic; n=27 in each subgroup), subjects with unipolar depression (n=26), subjects with anxiety disorders (n=25), and non-clinical controls (n=27) matched for age, gender, ethnicity, education, and premorbid IQ. Experimental tasks assessed cognitive (non-emotional) measures of mental imagery (cognitive stages). Questionnaires, experimental tasks, and a phenomenological interview assessed subjective domains including spontaneous imagery use, interpretation bias, and emotional mental imagery.

results(i) Compared to non-clinical controls, the BD combined group reported a greater impact of intrusive prospective imagery in daily life, more vivid and "real" negative images (prospective imagery task), and higher self-involvement (picture-word task). The BD combined group showed no clear abnormalities in cognitive stages of mental imagery. (ii) When depressed individuals with BD were compared to the depressed or anxious clinical control groups, no significant differences remained-across all groups, imagery differences were associated with affective lability and anxiety.

conclusionsCompared to non-clinical controls, BD is characterized by abnormalities in aspects of emotional mental imagery within the context of otherwise normal cognitive aspects. When matched for depression and anxiety, these abnormalities are not specific to BD-rather, imagery may reflect a transdiagnostic marker of emotional psychopathology.

Indexed as

AnxietyBipolar DisorderDepressionImaginationAdultFemaleHumansInterview, PsychologicalMaleProspective StudiesPsychopathologyStatistics as TopicSurveys and Questionnairesaffective labilityanxietybipolar disordercognitive functioningdepressionmental imagery

Identifiers

PMID27995690
PMCPMC5299482
OpenAlexW2564501081

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.