Evidence map›Paper›PMID 27995646›Full record

ArticleThe Journal of physiology2017

Bicarbonate-rich fluid secretion predicted by a computational model of guinea-pig pancreatic duct epithelium.

Makoto Yamaguchi, Martin C Steward, Kieran Smallbone, Yoshiro Sohma, Akiko Yamamoto, Shigeru B H Ko, Takaharu Kondo, Hiroshi Ishiguro

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Bicarbonate secretion and acid/base sensing by the intestine.Pflugers Archiv : European journal of physiology · 2024
    Review
  3. Article
  4. Review
  5. WNK Inhibition Increases Surface Liquid pH and Host Defense in Cystic Fibrosis Airway Epithelia.American journal of respiratory cell and molecular biology · 2022
    Article
  6. Review
  7. Mouse pancreatic ductal organoid culture as a relevant model to study exocrine pancreatic ion secretion.Laboratory investigation; a journal of technical methods and pathology · 2020
    Article
  8. ClAmerican journal of physiology. Cell physiology · 2020
    Review
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Makoto YamaguchiDepartment of Human Nutrition, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Martin C StewardSchool of Medical Sciences.
Kieran SmallboneSchool of Computer Science, University of Manchester, Manchester, UK.
Yoshiro SohmaDepartment of Pharmacology, School of Medicine.
Akiko YamamotoDepartment of Human Nutrition, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Shigeru B H KoDepartment of Systems Medicine, Keio University, Tokyo, Japan.
Takaharu KondoDepartment of Human Nutrition, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Hiroshi IshiguroDepartment of Human Nutrition, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID 0000-0002-3603-0987
Nagoya University · JPKeio University · JPUniversity of Manchester · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

key pointsThe ductal system of the pancreas secretes large volumes of alkaline fluid containing HCO ABSTRACT: A computational model of guinea-pig pancreatic duct epithelium was developed to determine the transport mechanism by which HCO

Indexed as

AnimalsBicarbonatesBiological TransportCell MembraneChloridesEpitheliumGuinea PigsMembrane PotentialsMembrane Transport ProteinsModels, BiologicalPancreatic DuctsBicarbonatesChloridesMembrane Transport Proteinsbicarbonate secretioncomputational modelpancreatic duct

Identifiers

PMID27995646
PMCPMC5350461
OpenAlexW2566596447

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.