ReviewMolecular diagnosis & therapy2017
Somatic Mutations in Prostate Cancer: Closer to Personalized Medicine.
Review in Molecular diagnosis & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 19 citations in OpenAlex.
- PTEN-knockout regulates metabolic rewiring and epigenetic reprogramming in prostate cancer and chemoprevention by triterpenoid ursolic acid.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Detection of disease-causing mutations in prostate cancer by NGS sequencing.Cell biology international · 2022Article
- The importance of personalized medicine in urological cancers.Journal of diabetes and metabolic disorders · 2022Review
- Comprehensive analysis of tumour mutational burden and its clinical significance in prostate cancer.BMC urology · 2021Article
- Identification and Validation of SNP-Containing Genes With Prognostic Value in Gastric CancerFrontiers in oncology · 2021Article
- Gene characteristics predicting missense, nonsense and frameshift mutations in tumor samples.BMC bioinformatics · 2018Article
- Comparative Proteome Profiling and Mutant Protein Identification in Metastatic Prostate Cancer Cells by Quantitative Mass Spectrometry-based Proteogenomics.Cancer genomics & proteomicsArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The molecular cause of prostate cancer (PCa) is still unclear; however, its progression involves androgen, PI3K/Akt, and PTEN signaling, as cycle and apoptotic pathways. Alterations in oncogenes and tumor suppressor genes as PIK3CA, BRAF, KRAS and TP53 are not very common. Recently, somatic mutations have been discovered in relation to cancer progression mainly in genes such as PIK3CA; however, little data has been described in PCa. Nowadays genetic tools allow us to investigate multiple details about the biological heterogeneity of PCa, to better understand the mechanisms of disease progression and treatment resistance. Therefore, if the most relevant somatic mutations were included during screening, we could identify the best treatment for the right patient, bringing us closer to personalized medicine. The main objective of this article is to provide a review of the principal somatic mutations that appear to have a relevant role in hormonal cancers, like prostate cancer.
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Registered trials
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