ReviewEndocrine2017
Adrenal crises: perspectives and research directions.
Review in Endocrine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 78 citations in OpenAlex.
- Risk and outcomes of adrenal crisis in primary adrenal insufficiency: Evidence from a 24-year nationwide cohort study.Journal of internal medicine · 2026Article
- Article
- Adrenal crisis: incidence, clinical presentation and risk factors in patients with Addison's disease.Endocrine · 2025Article
- Clinical characteristics of acute adrenal insufficiency in emergency patients: an analysis of data in Lhasa, Xizang Autonomous Region of China.World journal of emergency medicine · 2025Article
- A national survey of Brazilian endocrinologists' practices in educating patients with adrenal insufficiency on stress-induced glucocorticoid adjustments.Archives of endocrinology and metabolism · 2025Article
- Iatrogenic adrenal insufficiency in adults.Nature reviews. Endocrinology · 2024Review
- Undiagnosed adrenal insufficiency as a cause of premature death in glucocorticoid users.Endocrine connections · 2024Article
- Clinical characteristics of adrenal crisis in 371 adult patients with glucocorticoid-induced adrenal insufficiency.Frontiers in endocrinology · 2024Article
- Electrolyte abnormalities and stress dosing predict illness-related hospitalizations among infants and toddlers with congenital adrenal hyperplasia.Clinical endocrinology · 2023Article
- Tuberculosis of Adrenal Glands-A Population-based Case-control Study.Journal of the Endocrine Society · 2023Article
- Adrenal crises in adolescents and young adults.Endocrine · 2022Review
- Trends in hospital admissions for adrenal insufficiency in adolescents and young adults in the 21Frontiers in endocrinology · 2022Article
- Improving the Interpretation of Afternoon Cortisol Levels and SSTs to Prevent Misdiagnosis of Adrenal Insufficiency.Journal of the Endocrine Society · 2021Article
- The epidemiology of primary and secondary adrenal malignancies and associated adrenal insufficiency in hospitalised patients: an analysis of hospital admission data, NSW, Australia.BMC endocrine disorders · 2021Article
- Use of medical identification jewellery in children and young adults with adrenal insufficiency in Australia.Endocrine · 2021Article
- Interaction between hypotension and age on adrenal crisis diagnosis.Endocrinology, diabetes & metabolism · 2021Article
- Adrenal insufficiency.Nature reviews. Disease primers · 2021Review
- Challenging Diagnosis of Addison's Disease Presenting with Adrenal Crisis.Case reports in endocrinology · 2021Article
- Hypopituitarism manifesting after invasive dental treatment in a patient with carcinoma of the tongue: a case report.BMC oral health · 2020Article
- Prehospital Management of Acute Addison Disease: Audit of Patients Attending a Referral Hospital in a Regional Area.Journal of the Endocrine Society · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adrenal crises are life-threatening complications of adrenal insufficiency. These events have an estimated incidence of between 5 and 10 adrenal crises/100 patient years and are responsible for some of the increased morbidity and excess mortality experienced by patients with adrenal insufficiency. Treatment involves urgent administration of IV/IM hydrocortisone and IV fluids. Patient education regarding preventive measures, such as increasing the dose of replacement therapy ("stress dosing") when sick, using parenteral hydrocortisone as necessary and accessing medical assistance promptly, is still considered the best approach to averting the onset of an adrenal crisis at times of physiological stress, most commonly an infection. However, recent evidence has demonstrated that patient education does not prevent many adrenal crisis events and the reasons for this are not fully understood. Furthermore, there is no widely accepted definition of an adrenal crisis. Without a validated adrenal crisis definition it is difficult to interpret variations in the incidence of adrenal crises and determine the effectiveness of preventive measures. This article aims to review the clinical aspects of adrenal crisis events, to explore the epidemiology, and to offer a definition of an adrenal crisis and to offer a perspective on future directions for research into adrenal crisis prevention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.