Evidence map›Paper›PMID 27995384›Full record

ArticleClinical rheumatology2017

Quantitative imaging by pixel-based contrast-enhanced ultrasound reveals a linear relationship between synovial vascular perfusion and the recruitment of pathogenic IL-17A-F

Ugo Fiocco, Roberto Stramare, Veronica Martini, Alessandro Coran, Francesco Caso, Luisa Costa, Mara Felicetti, Gaia Rizzo, Matteo Tonietto, Anna Scanu and 10 more

Abstract read
PubMed Publisher
In one paragraph

Article in Clinical rheumatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. IL-23 orchestrating immune cell activation in arthritis.Rheumatology (Oxford, England) · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 2 institutions in 1 country.

Ugo FioccoRheumatology Unit, Department of Medicine, University of Padova, Via Giustiniani, 2, 35128, Padova, Italy. ugo.fiocco@unipd.it.
Roberto StramareSection of Radiology, Department of Medicine, University of Padova, Via Giustiniani, 2, 35128, Padova, Italy.
Veronica MartiniHaematology and Clinical Immunology Branch, University of Padova, Via Giustiniani, 2, 35128, Padova, Italy.
Alessandro CoranSection of Radiology, Department of Medicine, University of Padova, Via Giustiniani, 2, 35128, Padova, Italy.
Francesco CasoRheumatology Unit, Department of Clinical Medicine and Surgery, University Federico II, via S. Pansini 5, 80131, Naples, Italy.
Luisa CostaRheumatology Unit, Department of Clinical Medicine and Surgery, University Federico II, via S. Pansini 5, 80131, Naples, Italy.
Mara FelicettiRheumatology Unit, Department of Medicine, University of Padova, Via Giustiniani, 2, 35128, Padova, Italy.
Gaia RizzoDepartment of Information Engineering, University of Padova, Via Giustiniani, 2, 35128, Padova, Italy.
Matteo ToniettoDepartment of Information Engineering, University of Padova, Via Giustiniani, 2, 35128, Padova, Italy.
Anna ScanuRheumatology Unit, Department of Medicine, University of Padova, Via Giustiniani, 2, 35128, Padova, Italy.
Francesca OlivieroRheumatology Unit, Department of Medicine, University of Padova, Via Giustiniani, 2, 35128, Padova, Italy.
Bernd RaffeinerRheumatology Unit, Department of Medicine, University of Padova, Via Giustiniani, 2, 35128, Padova, Italy.
Maristella VezzùRheumatology Unit, Department of Medicine, University of Padova, Via Giustiniani, 2, 35128, Padova, Italy.
Francesca LunardiDepartment of Cardiac, Thoracic and Vascular Sciences - Section of Anatomy Pathology, University of Padova, Via Giustiniani, 2, 35128, Padova, Italy.
Raffaele ScarpaRheumatology Unit, Department of Clinical Medicine and Surgery, University Federico II, via S. Pansini 5, 80131, Naples, Italy.
David SacerdotiDepartment of Medicine, Unit of Ultrasonography in Internal Medicine, University of Padova, Via Giustiniani, 2, 35128, Padova, Italy.
Leopoldo RubaltelliSection of Radiology, Department of Medicine, University of Padova, Via Giustiniani, 2, 35128, Padova, Italy.
Leonardo PunziRheumatology Unit, Department of Medicine, University of Padova, Via Giustiniani, 2, 35128, Padova, Italy.
Andrea DoriaRheumatology Unit, Department of Medicine, University of Padova, Via Giustiniani, 2, 35128, Padova, Italy.
Enrico GrisanDepartment of Information Engineering, University of Padova, Via Giustiniani, 2, 35128, Padova, Italy.
University of Padua · ITFederico II University Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To develop quantitative imaging biomarkers of synovial tissue perfusion by pixel-based contrast-enhanced ultrasound (CEUS), we studied the relationship between CEUS synovial vascular perfusion and the frequencies of pathogenic T helper (Th)-17 cells in psoriatic arthritis (PsA) joints. Eight consecutive patients with PsA were enrolled in this study. Gray scale CEUS evaluation was performed on the same joint immediately after joint aspiration, by automatic assessment perfusion data, using a new quantification approach of pixel-based analysis and the gamma-variate model. The set of perfusional parameters considered by the time intensity curve includes the maximum value (peak) of the signal intensity curve, the blood volume index or area under the curve, (BVI, AUC) and the contrast mean transit time (MTT). The direct ex vivo analysis of the frequencies of SF IL17A-F

Indexed as

AdultAgedArea Under CurveArthritis, PsoriaticBiomarkersCD4-Positive T-LymphocytesCell SeparationContrast MediaFemaleFlow CytometryHumansInflammationInterleukin-17Interleukin-23 Subunit p19JointsLeukocytes, MononuclearBiomarkersContrast MediaIL17A protein, humanIL23A protein, humanInterleukin-17Interleukin-23 Subunit p19NK Cell Lectin-Like Receptor Subfamily BImaging ultrasoundInterleukin-17Psoriatic arthritisQuantitative imagingT cells

Identifiers

PMID27995384
OpenAlexW2564571483

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.