ArticleClinical rheumatology2017
Latitude gradient influences the age of onset of rheumatoid arthritis: a worldwide survey.
Article in Clinical rheumatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Association Between Rheumatoid Arthritis and Risk of Parkinson's Disease: A Meta-Analysis and Systematic Review.Frontiers in neurology · 2022Pooled it
- Sarcopenia in osteoarthritis and rheumatoid arthritis: The association with self-reported fatigue, physical function and obesity.PloS one · 2019Trial
- Pregnancy Outcomes for Indigenous Females With Rheumatoid Arthritis in Western Australia.International journal of rheumatic diseases · 2026Article
- Natural environmental factors at birth on risk for rheumatoid arthritis: the impact of season, temperature, latitude, and sunlight exposure.BMC public health · 2025Article
- Immunological landscape of periodontitis and rheumatoid arthritis and their molecular crosstalk.European journal of medical research · 2025Article
- Review
- Management of refractory disease and persistent symptoms in inflammatory arthritis: qualitative framework analysis of interviews with patients and healthcare professionals.Rheumatology advances in practice · 2024Article
- Tocilizumab Reduces Depression Risk in Rheumatoid Arthritis Patients: A Systematic Review and Meta-Analysis.Psychology research and behavior management · 2024Review
- Secular trend of mortality and incidence of rheumatoid arthritis in global ,1990-2019: an age period cohort analysis and joinpoint analysis.BMC pulmonary medicine · 2023Article
- Development of a nomogram to predict medication nonadherence risk in patients with rheumatoid arthritis.American journal of translational research · 2022Article
- Interleukin 6, interleukin 17, disease-related and contextual factor association with depression, and its severity in patients with rheumatoid arthritis.Clinical rheumatology · 2021Article
- Does healthcare regime affiliation influence the clinical outcomes of patients with rheumatoid arthritis?Clinical rheumatology · 2021Observational
- Environment and Lifestyle: Their Influence on the Risk of RA.Journal of clinical medicine · 2020Review
- Evaluation of Risk Factors for Falls in Patients with Rheumatoid Arthritis.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Advances in rheumatology practice in Brazil.Rheumatology international · 2019Review
- Evaluation of disease activity in a low-income juvenile idiopathic arthritis cohort.Rheumatology international · 2019Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The age of onset of rheumatoid arthritis (RA) is an important outcome predictor. Northern countries report an age of RA onset of around 50 years, but apparently, variability exists across different geographical regions. The objective of the present study is to assess whether the age of onset of RA varies across latitudes worldwide. In a proof-of-concept cross-sectional worldwide survey, rheumatologists from preselected cities interviewed 20 consecutive RA patients regarding the date of RA onset (RAO, when the patient first noted a swollen joint). Other studied variables included location of each city, rheumatologist settings, latitudes (10° increments, south to north), longitudes (three regions), intracountry consistency, and countries' Inequality-adjusted Human Development Index (IHDI). Data from 2481 patients (82% females) were obtained from 126 rheumatologists in 77 cities of 41 countries. Worldwide mean age of RAO was 44 ± 14 years (95% CI 44-45). In 28% of patients, RA began before age 36 years and before age 46 years in 50% of patients. RAO was 8 years earlier around the Tropic of Cancer when compared with northern latitudes (p < 0.001, 95% CI 3.5-13). Multivariate analysis showed that females, western cities, and latitudes around the Tropic of Cancer are associated with younger age of RAO (R
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