Evidence map›Paper›PMID 27995364›Full record

ArticleBasic research in cardiology2017

Transition in the mechanism of flow-mediated dilation with aging and development of coronary artery disease.

Andreas M Beyer, Natalya Zinkevich, Bradley Miller, Yanping Liu, April L Wittenburg, Michael Mitchell, Ralph Galdieri, Andrey Sorokin, David D Gutterman

Open access · greenAbstract read
In one paragraph

Article in Basic research in cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 89 citations in OpenAlex.

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  3. The role of NO, HBasic research in cardiology · 2025
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  7. Endothelial TERT drives microvascular phenotype associated with coronary artery disease.American journal of physiology. Heart and circulatory physiology · 2025
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  9. Sexually dimorphic mechanisms of HJournal of applied physiology (Bethesda, Md. : 1985) · 2025
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  12. Integrating molecular and cellular components of endothelial shear stress mechanotransduction.American journal of physiology. Heart and circulatory physiology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Andreas M BeyerDepartment of Medicine, Medical College of Wisconsin, Milwaukee, USA. abeyer@mcw.edu.ORCID 0000-0001-9129-7492
Natalya ZinkevichDepartment of Medicine, Medical College of Wisconsin, Milwaukee, USA.
Bradley MillerDepartment of Medicine, Medical College of Wisconsin, Milwaukee, USA.
Yanping LiuNIH NIGMS, Bethesda, USA.
April L WittenburgDepartment of Physiology, Cardiovascular Center, Medical College of Wisconsin, HRC H4875, 8701 Watertown Plank Rd., Milwaukee, WI, 53226, USA.
Michael MitchellChildren's Hospital of Wisconsin, Wauwatosa, USA.
Ralph GaldieriWheaton Franciscan Healthcare, Wheaton, USA.
Andrey SorokinDepartment of Medicine, Medical College of Wisconsin, Milwaukee, USA.
David D GuttermanDepartment of Medicine, Medical College of Wisconsin, Milwaukee, USA.
Medical College of Wisconsin · USChildren's Hospital of Wisconsin · USNational Institute of General Medical Sciences · USWheaton Franciscan Healthcare · US

Funding

Clincal and Translational Science AwardUL1TR000055 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI SHAKER, REZA NONE · 2012 to 2015
$11.3M
Flow-Mediated Dilation of Human Coronary ArteriolesR01HL080704 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI GUTTERMAN, DAVID D. · 2006 to 2010
$1.8M
Mechanism of Flow-Induced Dilation in the Human MicrocirculationR01HL113612 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI GUTTERMAN, DAVID D. · 2013 to 2016
$1.7M
Role of Hydrogen Peroxide in the Mechanism of Flow-Induced Dilation of the Human R01HL094971 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI GUTTERMAN, DAVID D. · 2009 to 2012
$1.5M
Differentiation of mitochondrial vs. nuclear function of telomeraseR21OD018306 · OD · MEDICAL COLLEGE OF WISCONSIN · PI BEYER, ANDREAS M · 2014 to 2015
$411k
NCATS NIH HHS UL1 TR000055NHLBI NIH HHS R01 HL080704NHLBI NIH HHS R01 HL094971NHLBI NIH HHS R01 HL113612NIH HHS R21 OD018306
6 · The paper itself

Abstract

In microvessels of patients with coronary artery disease (CAD), flow-mediated dilation (FMD) is largely dependent upon the endothelium-derived hyperpolarizing factor H

Indexed as

AdolescentAdultAgingBlotting, WesternChildChild, PreschoolCoronary Artery DiseaseCoronary VesselsFemaleHumansImmunohistochemistryInfantInfant, NewbornMaleMiddle AgedReactive Oxygen SpeciesReactive Oxygen SpeciesCoronary artery diseaseFlow-mediated dilationMicrovasculatureVasodilation

Identifiers

PMID27995364
PMCPMC6758541
OpenAlexW2565393051

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.