Evidence map›Paper›PMID 27995357›Full record

ArticleInflammation2017

Bone Morphogenetic Protein-Modulator BMPER Regulates Endothelial Barrier Function.

Thomas Helbing, Gwendoline Wiltgen, Alexandra Hornstein, Elena Z Brauers, Linus Arnold, Adrian Bauer, Jennifer S Esser, Philipp Diehl, Sebastian Grundmann, Katrin Fink and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 29 citations in OpenAlex.

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  18. Bone morphogenetic protein signaling in inflammation.Experimental biology and medicine (Maywood, N.J.) · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Thomas HelbingDepartment of Cardiology and Angiology, Heart Center Freiburg University, Hugstetter Strasse 55, 79106, Freiburg im Breisgau, Germany. thomas.helbing@universitaets-herzzentrum.de.
Gwendoline WiltgenDepartment of Cardiology and Angiology, Heart Center Freiburg University, Hugstetter Strasse 55, 79106, Freiburg im Breisgau, Germany.
Alexandra HornsteinDepartment of Cardiology and Angiology, Heart Center Freiburg University, Hugstetter Strasse 55, 79106, Freiburg im Breisgau, Germany.
Elena Z BrauersDepartment of Cardiology and Angiology, Heart Center Freiburg University, Hugstetter Strasse 55, 79106, Freiburg im Breisgau, Germany.
Linus ArnoldDepartment of Cardiology and Angiology, Heart Center Freiburg University, Hugstetter Strasse 55, 79106, Freiburg im Breisgau, Germany.
Adrian BauerDepartment of Cardiology and Angiology, Heart Center Freiburg University, Hugstetter Strasse 55, 79106, Freiburg im Breisgau, Germany.
Jennifer S EsserDepartment of Cardiology and Angiology, Heart Center Freiburg University, Hugstetter Strasse 55, 79106, Freiburg im Breisgau, Germany.
Philipp DiehlDepartment of Cardiology and Angiology, Heart Center Freiburg University, Hugstetter Strasse 55, 79106, Freiburg im Breisgau, Germany.
Sebastian GrundmannDepartment of Cardiology and Angiology, Heart Center Freiburg University, Hugstetter Strasse 55, 79106, Freiburg im Breisgau, Germany.
Katrin FinkFaculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany.
Cam PattersonMcAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Christoph BodeDepartment of Cardiology and Angiology, Heart Center Freiburg University, Hugstetter Strasse 55, 79106, Freiburg im Breisgau, Germany.
Martin MoserDepartment of Cardiology and Angiology, Heart Center Freiburg University, Hugstetter Strasse 55, 79106, Freiburg im Breisgau, Germany.
University of Freiburg · DEPresbyterian Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The endothelium serves as a selective barrier and controls the exchange of nutrients, hormones, and leukocytes between blood and tissues. Molecular mechanisms contributing to the pathogenesis of endothelial barrier dysfunction remain incompletely understood. Accumulating evidence implicates bone morphogenetic protein (BMP)-modulator BMPER as a key regulator in endothelial biology. Herein, we analyze the impact of BMPER in the control of endothelial barrier function. To assess the role of BMPER in vascular barrier function in mice, we measured the leakage of Evans blue dye from blood into interstitial lung tissue. BMPER

Indexed as

AnimalsAntigens, CDBone Morphogenetic Protein 4Bone Morphogenetic ProteinsCadherin 5CadherinsCapillary PermeabilityCarrier ProteinsEndothelium, VascularHumansMiceMice, Inbred C57BLRNA, Small InterferingSignal TransductionAntigens, CDBMP4 protein, humanBMPER protein, humanBone Morphogenetic Protein 4Bone Morphogenetic ProteinsCadherin 5CadherinsCarrier ProteinsRNA, Small InterferingBMP4BMPERendothelial barrier functionSmadVE-cadherin

Identifiers

PMID27995357
OpenAlexW2563110763

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.