ArticleCancer causes & control : CCC2017
Diabetes and breast cancer mortality in Black women.
Article in Cancer causes & control : CCC, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Plasma exosomes in insulin resistant obesity exacerbate progression of triple negative breast cancer.BMC cancer · 2025Article
- Insulin Resistance Increases TNBC Aggressiveness and Brain Metastasis via Adipocyte-Derived Exosomes.Molecular cancer research : MCR · 2025Article
- Diabetes-associated breast cancer is molecularly distinct and shows a DNA damage repair deficiency.JCI insight · 2023Article
- Diabetes and cancer co-management: patient-reported challenges, needs, and priorities.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Racial disparities in triple negative breast cancer: toward a causal architecture approach.Breast cancer research : BCR · 2022Article
- Type 2 Diabetes and all-cause mortality among Spanish women with breast cancer.Cancer causes & control : CCC · 2022Article
- The crosstalk within the breast tumor microenvironment in type II diabetes: Implications for cancer disparities.Frontiers in endocrinology · 2022Review
- Racial/ethnic disparities in risk of breast cancer mortality by molecular subtype and stage at diagnosis.Breast cancer research and treatment · 2021Article
- Adipocyte-derived exosomes may promote breast cancer progression in type 2 diabetes.Science signaling · 2021Article
- Consumption of sugar-sweetened and artificially sweetened beverages and breast cancer survival.Cancer · 2021Article
- Preexisting morbidity profile of women newly diagnosed with breast cancer in sub-Saharan Africa: African Breast Cancer-Disparities in Outcomes study.International journal of cancer · 2021Article
- Social Determinants of Racial Disparities in Breast Cancer Mortality Among Black and White Women.Journal of racial and ethnic health disparities · 2021Article
- Patterns of chronic disease management and health outcomes in a population-based cohort of Black women with breast cancer.Cancer causes & control : CCC · 2021Article
- Examining COVID-19 Preventive Behaviors among Cancer Survivors in the United States: An Analysis of the COVID-19 Impact Survey.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- Article
- The Devastating Impact of the COVID-19 Pandemic on Breast Cancer Care Among Medically Underserved Populations at Two New York City Public Hospitals.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2020Article
- Variation in Breast Cancer Subtype Incidence and Distribution by Race/Ethnicity in the United States From 2010 to 2015.JAMA network open · 2020Article
- Diabetes and cardiovascular disease mortality among a population-based cohort of women with and without breast cancer.Cancer causes & control : CCC · 2020Article
- Article
- Diabetes Mellitus and Cause-Specific Mortality: A Population-Based Study.Diabetes & metabolism journal · 2019Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
purposeBreast cancer mortality is higher in Black women than in White women. The prevalence of type 2 diabetes mellitus is also higher, yet data on whether diabetes affects breast cancer mortality in this population are lacking. We investigated the relation of diabetes at the time of breast cancer diagnosis to breast cancer mortality in the Black Women's Health Study, a prospective cohort study.
methods1,621 Black women with invasive breast cancer diagnosed in 1995-2013 were followed by mailed questionnaires and searches of the National Death Index. Multivariable Cox regression analysis was used to compute hazard ratios (HRs) for diabetes in relation to breast cancer mortality and all-cause mortality, with adjustment for age, stage, treatment modality, estrogen receptor (ER) status, and body mass index.
resultsThere were 368 deaths during follow-up, of which 273 were due to breast cancer. Breast cancer mortality was significantly increased in women who had been diagnosed with diabetes at least 5 years before breast cancer occurrence, HR 1.86 (95% CI 1.20-2.89), with elevations observed for both ER+ and ER- breast cancer. All-cause mortality was also higher in diabetics, with HRs of 1.54 (95% CI 1.12-2.07) overall and 2.26 (95% CI 1.62-3.15) for ≥5-year duration of diabetes relative to non-diabetics.
conclusionsOur results present the first solid evidence of a positive association of type 2 diabetes with breast cancer mortality in Black women. Given the higher prevalence and earlier onset of type 2 diabetes in Black women, it is likely that diabetes contributes to racial disparities in breast cancer mortality.
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