ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2017
Genome-wide mapping and prediction suggests presence of local epistasis in a vast elite winter wheat populations adapted to Central Europe.
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Haplotype applications in genomic selection.Genome biology · 2026Review
- Contribution of crossing over to genetic variance in maize and wheat populations.The plant genome · 2025Article
- Improvement of crop production in controlled environment agriculture through breeding.Frontiers in plant science · 2024Review
- Sparse Phenotyping and Haplotype-Based Models for Genomic Prediction in Rice.Rice (New York, N.Y.) · 2023Article
- Multi-Trait Genomic Prediction Models Enhance the Predictive Ability of Grain Trace Elements in Rice.Frontiers in genetics · 2022Article
- NeuralLasso: Neural Networks Meet Lasso in Genomic Prediction.Frontiers in plant science · 2022Article
- Optimizing the setup of multienvironmental hybrid wheat yield trials for boosting the selection capability.The plant genome · 2021Article
- Unlocking big data doubled the accuracy in predicting the grain yield in hybrid wheat.Science advances · 2021Article
- Linkage disequilibrium patterns, population structure and diversity analysis in a worldwide durum wheat collection including Argentinian genotypes.BMC genomics · 2021Article
- Utilization of a Wheat55K SNP array-derived high-density genetic map for high-resolution mapping of quantitative trait loci for important kernel-related traits in common wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Assessing the Suitability of Elite Lines for Hybrid Seed Production and as Testers in Wide Crosses With Wheat Genetic Resources.Frontiers in plant science · 2021Article
- A haplotype-led approach to increase the precision of wheat breeding.Communications biology · 2020Article
- Suitability of Single-Nucleotide Polymorphism Arrays Versus Genotyping-By-Sequencing for Genebank Genomics in Wheat.Frontiers in plant science · 2020Article
- Extension of a haplotype-based genomic prediction model to manage multi-environment wheat data using environmental covariates.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2019Article
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- Imperfect Linkage Disequilibrium Generates Phantom Epistasis (& Perils of Big Data).G3 (Bethesda, Md.) · 2019Article
- Reciprocal recurrent genomic selection: an attractive tool to leverage hybrid wheat breeding.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2019Review
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- Article
- Optimising Genomic Selection in Wheat: Effect of Marker Density, Population Size and Population Structure on Prediction Accuracy.G3 (Bethesda, Md.) · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
key messageGenome-wide association mapping as well as marker- and haplotype-based genome-wide selection unraveled a complex genetic architecture of grain yield with absence of large effect QTL and presence of local epistatic effects. The genetic architecture of grain yield determines to a large extent the optimum design of genomic-assisted wheat breeding programs. The main goal of our study was to examine the potential and limitations to dissect the genetic architecture of grain yield in wheat using a large experimental data set. Our study was based on phenotypic information and genomic data of 13,901 SNPs of a diverse set of 3816 elite wheat lines adapted to Central Europe. We applied genome-wide association mapping based on experimental and simulated data sets and performed marker- and haplotype-based genomic prediction. Computer simulations revealed for our mapping population a high power to detect QTL, even if they individually explained only 2.5% of the genetic variation. Despite this, we found no stable marker-trait associations when validating in independent subsets. A two-dimensional scan for marker-marker interactions indicated presence of local epistasis which was further supported by improved prediction abilities when shifting from marker- to haplotype-based genome-wide prediction approaches. We observed that marker effects estimated using genome-wide prediction approaches strongly varied across years albeit resulting in high prediction abilities. Thus, our results suggested that the prediction accuracy of genomic selection in wheat is mainly driven by relatedness rather than by exploiting knowledge of the genetic architecture.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.