Evidence map›Paper›PMID 27995252›Full record

ArticleOrganic & biomolecular chemistry2017

Tracking the formation of supramolecular G-quadruplexes via self-assembly enhanced emission.

Diana Silva-Brenes, Loruhama Delgado, José M Rivera

Abstract read
In one paragraph

Article in Organic & biomolecular chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Diana Silva-BrenesDepartment of Chemistry and Molecular Sciences Research Center, University of Puerto Rico at Río Piedras, San Juan, 00926, Puerto Rico. riveralab.upr@gmail.com.
Loruhama DelgadoDepartment of Chemistry and Molecular Sciences Research Center, University of Puerto Rico at Río Piedras, San Juan, 00926, Puerto Rico. riveralab.upr@gmail.com.
José M RiveraDepartment of Chemistry and Molecular Sciences Research Center, University of Puerto Rico at Río Piedras, San Juan, 00926, Puerto Rico. riveralab.upr@gmail.com.ORCID http://orcid.org/0000-0001-7089-7640

Funding

Upgrade Laboratories Facilities at UPR-Rio PiedrasR25GM061151 · NIGMS · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · PI CARBALLEIRA, NESTOR MANUEL · 2001 to 2023
$32.5M
Small Molecule Self-Assembly in Aqueos MediaSC1GM093994 · NIGMS · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · PI RIVERA, JOSE M · 2010 to 2013
$1.3M
NIGMS NIH HHS R25 GM061151NIGMS NIH HHS SC1 GM093994
6 · The paper itself

Abstract

We report the synthesis and self-assembly of two lipophilic 2'-deoxyguanosine (G) derivatives whose fluorescence intensity is modulated by self-assembly into supramolecular G-quadruplexes (SGQs). Whereas both derivatives self-assemble isostructurally, one shows up to 100% emission enhancement while the other shows an initial enhancement, followed by 10% quenching. Thus, the rotational restrictions resulting from self-assembly are enough to induce significant changes in emission, but it is critical to consider the specific interactions between fluorophores since they will determine the ultimate emission signature. These findings could open the door to the development of luminescent supramolecular sensors and probes.

Indexed as

G-QuadruplexesDeoxyguanosineFluorescenceMacromolecular SubstancesModels, MolecularMolecular StructureDeoxyguanosineMacromolecular Substances

Identifiers

PMID27995252
PMCPMC5315060

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.