ArticleMaxillofacial plastic and reconstructive surgery2016
Effect of low-level laser therapy on bisphosphonate-treated osteoblasts.
Article in Maxillofacial plastic and reconstructive surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- How to Prepare Patients Receiving Antiresorptive Therapy for Tooth Extraction: A Narrative Review.International journal of molecular sciences · 2026Review
- The effect of low-level laser therapy on osteoclast differentiation: Clinical implications for tooth movement and bone density.Journal of dental sciences · 2024Article
- In vivo efficacy of low-level laser therapy on bone regeneration.Lasers in medical science · 2022Article
- Effects of photobiomodulation on bone remodeling in an osteoblast-osteoclast co-culture system.Lasers in medical science · 2022Article
- Schemes for Drug-Induced Treatment of Osteonecrosis of Jaws with Particular Emphasis on the Influence of Vitamin D on Therapeutic Effects.Pharmaceutics · 2021Review
- In Vitro Cytological Responses against Laser Photobiomodulation for Periodontal Regeneration.International journal of molecular sciences · 2020Review
- Combined effect of recombinant human bone morphogenetic protein-2 and low level laser irradiation on bisphosphonate-treated osteoblasts.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2018Article
- Clinical characteristics and recurrence-related factors of medication-related osteonecrosis of the jaw.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2018Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study investigates the effect of alendronate-treated osteoblasts, as well as the effect of low-level laser therapy (LLLT) on the alendronate-treated osteoblasts. Bisphosphonate decreases the osteoblastic activity. Various treatment modalities are used to enhance the bisphosphonate-treated osteoblasts; however, there were no cell culture studies conducted using a low-level laser.
methodsHuman fetal osteoblastic (hFOB 1.19) cells were treated with 50 μM alendronate. Then, they were irradiated with a 1.2 J/cm
resultsIn the cells treated with alendronate at concentrations of 50 μM and higher, cell survivability significantly decreased after 48 h (
conclusionsThe LLLT does not affect the OPG expression in the hFOB cell line, but it may increase the RANKL and M-CSF expressions, thereby resulting in positive effects on osteoclastogenesis and bone remodeling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.