ArticleProstate international2016
Gleason group concordance between biopsy and radical prostatectomy specimens: A cohort study from Prostate Cancer Outcome Registry - Victoria.
Article in Prostate international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 59 citations in OpenAlex.
- Gleason Regrading After Prostatectomy-Results From the Irish Prostate Cancer Outcome Research (IPCOR) Situated in the International Context.International journal of urology : official journal of the Japanese Urological Association · 2026Article
- Factors influencing Gleason score up/downgrade in radical prostatectomy.BMC urology · 2025Article
- Evaluating the feasibility of AI-predicted bpMRI image features for predicting prostate cancer aggressiveness: a multi-center study.Insights into imaging · 2025Article
- Prostate cancer lesions in transition zone exhibit a higher propensity for pathological upgrading in radical prostatectomy.World journal of urology · 2024Article
- Histopathological concordance between prostate biopsies and radical prostatectomy specimens-implications of transrectal and transperineal biopsy approaches.Prostate cancer and prostatic diseases · 2024Article
- Risk factors for Gleason score upgrade from prostate biopsy to radical prostatectomy.Exploration of targeted anti-tumor therapy · 2024Review
- Transfer Learning with Pretrained Convolutional Neural Network for Automated Gleason Grading of Prostate Cancer Tissue Microarrays.Journal of medical signals and sensors · 2024Article
- Comparing histology between prostate cognitive fusion targeted biopsy and radical prostatectomy: exploring risk factors of Gleason score upgrading in Chinese patients.Journal of cancer research and clinical oncology · 2023Article
- Impact of delay from transperineal biopsy to radical prostatectomy upon objective measures of cancer control.Asian journal of urology · 2022Article
- Evaluation of selective bone scan staging in prostate cancer - external validation of current strategies and decision-curve analysis.Prostate cancer and prostatic diseases · 2022Article
- Gleason grade accuracy of transperineal and transrectal prostate biopsies in MRI-naïve patients.International urology and nephrology · 2021Article
- The Urine Biomarker PUR-4 Is Positively Associated with the Amount of Gleason 4 in Human Prostate Cancers.Life (Basel, Switzerland) · 2021Article
- Analysis of risk factors for Gleason score upgrading after radical prostatectomy in a Chinese cohort.Cancer medicine · 2021Article
- Article
- Applications of Topological Data Analysis in Oncology.Frontiers in artificial intelligence · 2021Review
- Concordance Between Biopsy and Radical Prostatectomy Gleason Scores: Evaluation of Determinants in a Large-Scale Study of Patients Undergoing RARP in Belgium.Pathology oncology research : POR · 2020Article
- Radiologist-like artificial intelligence for grade group prediction of radical prostatectomy for reducing upgrading and downgrading from biopsy.Theranostics · 2020Article
- The factors predicting upgrading of prostate cancer by using International Society for Urological Pathology (ISUP) 2014 Gleason grading system.Turkish journal of urology · 2019Article
- Extent and predictors of grade upgrading and downgrading in an Australian cohort according to the new prostate cancer grade groupings.Asian journal of urology · 2019Article
- Deep learning for automatic Gleason pattern classification for grade group determination of prostate biopsies.Virchows Archiv : an international journal of pathology · 2019Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA new prostate cancer (PCa) prognostic grading system [Gleason groups (GGs)] has been proposed based on the contemporary Gleason scores (GSs), which has five simplified prognostic categories. The objective of this study was to evaluate the agreement between the GGs of prostate biopsy and radical prostatectomy specimens and to identify predictive factors for upgrading GGs.
methodsA total of 5339 cases of RP notified to the Prostate Cancer Outcomes Registry, Victoria, Australia over 6 years (2009-2014) from 46 hospitals, were included. The upgrading was evaluated using the new PCa prognostic grading system, the International Society of Urologic Pathology grade groups, which has five prognostic categories. GG 1 is GS ≤ 6, GG 2 is GS 3 + 4 = 7, GG 3 is GS 4 + 3 = 7, GG 4 is GS 8, and GG 5 is GS 9 and 10. Predictors of upgrading were assessed using univariate and multivariate models.
resultsThe GG of prostate biopsies and RP specimens were concordant in 54.5% of cases, while 31.1% were upgraded and 14.3% were downgraded. Longer time interval between biopsy and RP [44-99 days: odds ratio (OR) = 1.3, 95% confidence interval (CI) = 1.1-1.6; > 99 days: OR = 3.0, 95% CI = 2.4-3.8), and RP performed in a metropolitan hospital (biopsy in a regional hospital: OR = 2.2, 95% CI = 1.6-3.2, biopsy in a metropolitan hospital: OR = 1.7, 95% CI = 1.2-2.2) were significant predictors of GG upgrading. Patients who were diagnosed by transperineal biopsy compared to transrectal ultrasound (OR = 0.6, 95% CI = 0.5-0.8) and higher percentage of positive biopsy cassettes (25-62.5%: OR = 0.7, 95% CI = 0.6-0.8, > 62.5: OR = 0.6, 95% CI = 0.5-0.8) were significantly associated with less likelihood of upgrade.
conclusionThe lack of concordance among hospitals may be attributable to the specialist expertise of the pathologist. Expert review of specimens may help to overcome this discordance. Clinicians should consider clinical parameters and potential limitations of the GG at biopsy when making treatment decisions with regard to PCa.
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