Evidence map›Paper›PMID 27995084›Full record

ReviewLiver cancer2016

Hepatocellular Carcinoma: Therapeutic Guidelines and Medical Treatment.

Masatoshi Kudo, Franco Trevisani, Ghassan K Abou-Alfa, Lorenza Rimassa

Registry-linked trialAbstract readReview
In one paragraph

Review in Liver cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05557656 (A Real World Study of Regogfinib in the Treatment of Advanced Hepatocellular Carcinoma), which is not on this map. Cited by 59 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05557656 unknown statusnot on this mapstarted 2023, after this paper: background citation

A Real World Study of Regogfinib in the Treatment of Advanced Hepatocellular Carcinoma

TypeobservationalSponsorZhongda HospitalRan2023 to 2023Enrolled800ConditionsHepatocellular CarcinomaArmsRegorafenib 40 MG
3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Masatoshi KudoDepartment of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, OsakaSayama, Japan.
Franco TrevisaniSemeiotic Unit, Department of Medical and Surgical Sciences, Alma Mater Studiorum - University of Bologna, Bologna, Italy.
Ghassan K Abou-AlfaMemorial Sloan Kettering Cancer Center, N.Y., USA; Weill Cornell Medical College, N.Y., USA.
Lorenza RimassaMedical Oncology and Hematology Unit, Humanitas Cancer Center, Humanitas Clinical and Research Center, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Western and Eastern perspectives on therapeutic guidelines for hepatocellular carcinoma (HCC) have many commonalities but may also differ in certain aspects, as described in this article. In view of the limited therapeutic options for advanced HCC, evidence-based therapies are few, and thus there is a dependence on consensus-based guidelines. This article focuses on the Italian Association for the Study of the Liver guidelines and the Japanese approaches to therapy, while drawing attention to certain controversies from other academic bodies where applicable and appropriate.

Indexed as

Hepatocellular carcinomaPractice guidelineTreatmentTreatment algorithm

Identifiers

PMID27995084
PMCPMC5159738

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.