SynthesisNeuroImage. Clinical2016
Working memory circuit as a function of increasing age in healthy adolescence: A systematic review and meta-analyses.
Synthesis in NeuroImage. Clinical, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Memory deficits in children and adolescents with a psychotic disorder: a systematic review and meta-analysis.European archives of psychiatry and clinical neuroscience · 2025Pooled it
- Brain correlates of declarative memory atypicalities in autism: a systematic review of functional neuroimaging findings.Molecular autism · 2023Pooled it
- Phonological working memory is adversely affected in adults with anorexia nervosa: a systematic literature review.Eating and weight disorders : EWD · 2022Pooled it
- Single-dose effects of methylphenidate and atomoxetine on functional connectivity during an n-back task in boys with ADHD.Psychopharmacology · 2023Trial
- Connectome-based substrates of emotional N-back performance in the adolescent brain cognitive development study.Developmental cognitive neuroscience · 2026Article
- Age of Onset, Brain Controllability, and Working Memory Performance in First-Episode Schizophrenia.Schizophrenia bulletin · 2026Article
- Scaffolding Early Dialogue: A Unified Account of Response Contingency in Child-Caregiver Interaction.Cognitive science · 2026Article
- Associations among homocysteine, left cortical thickness, and working memory in patients with treatment-resistant schizophrenia: preliminary findings of a cohort study.BMC psychiatry · 2026Article
- Human amygdala nuclei show distinct developmental trajectories from adolescence to adulthood in functional integration with prefrontal circuitry.Cell reports · 2025Article
- Sex and age differences on how testosterone relates to brain activity during working memory among adolescents and young adults.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Non-invasive brain stimulation reorganises effective connectivity during a working memory task in individuals with Neurofibromatosis Type 1.Neuroimage. Reports · 2025Article
- Growing together: Dynamic connectivity between developmentally sensitive regions serving verbal working memory in children and adolescents.The Journal of physiology · 2025Article
- Distinct age-related alterations in alpha-beta neural oscillatory activity during verbal working memory encoding in children and adolescents.The Journal of physiology · 2025Article
- Effects of endogenous testosterone on oscillatory activity during verbal working memory in youth.Human brain mapping · 2024Article
- Stimulus shapes strategy: Effects of stimulus characteristics and individual differences in academic achievement on the neural mechanisms engaged during the N-back task.Developmental cognitive neuroscience · 2024Article
- [Neuroanatomical mapping of inhibitory attention and working memory with functional magnetic resonance imaging in healthy children].Revista de neurologia · 2024Article
- The longitudinal relationship between executive dysfunction and reactive and proactive aggression in adolescents: impulsivity as a mediator and sex differences.Frontiers in psychiatry · 2024Article
- Static and temporal dynamic changes of intrinsic brain activity in early-onset and adult-onset schizophrenia: a fMRI study of interaction effects.Frontiers in neurology · 2024Article
- Wearing a KN95/FFP2 facemask has no measureable effect on functional activity in a challenging working memory n-back task.Frontiers in human neuroscience · 2024Article
- Cognitive reserve and its correlates in child and adolescent offspring of patients diagnosed with schizophrenia or bipolar disorder.European child & adolescent psychiatry · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Working memory ability matures through puberty and early adulthood. Deficits in working memory are linked to the risk of onset of neurodevelopmental disorders such as schizophrenia, and there is a significant temporal overlap between the peak of first episode psychosis risk and working memory maturation. In order to characterize the normal working memory functional maturation process through this critical phase of cognitive development we conducted a systematic review and coordinate based meta-analyses of all the available primary functional magnetic resonance imaging studies (n = 382) that mapped WM function in healthy adolescents (10-17 years) and young adults (18-30 years). Activation Likelihood Estimation analyses across all WM tasks revealed increased activation with increasing subject age in the middle frontal gyrus (BA6) bilaterally, the left middle frontal gyrus (BA10), the left precuneus and left inferior parietal gyri (BA7; 40). Decreased activation with increasing age was found in the right superior frontal (BA8), left junction of postcentral and inferior parietal (BA3/40), and left limbic cingulate gyrus (BA31). These results suggest that brain activation during adolescence increased with age principally in higher order cortices, part of the core working memory network, while reductions were detected in more diffuse and potentially more immature neural networks. Understanding the process by which the brain and its cognitive functions mature through healthy adulthood may provide us with new clues to understanding the vulnerability to neurodevelopmental disorders.
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