Evidence map›Paper›PMID 27994723›Full record

ArticleCartilage2017

Return to Sports After Bone Marrow-Derived Cell Transplantation for Osteochondral Lesions of the Talus.

Francesca Vannini, Marco Cavallo, Laura Ramponi, Francesco Castagnini, Simone Massimi, Sandro Giannini, Roberto Emanuele Buda

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Cartilage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04883892 (BMAC vs HA in Infiltrative Therapy for Osteoarthritis of the Ankle), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04883892 naterminatednot on this mapstarted 2021, after this paper: background citation

BMAC vs HA in Infiltrative Therapy for Osteoarthritis of the Ankle: Randomized Controlled Clinical Trial

TypeinterventionalSponsorIstituto Ortopedico RizzoliRan2021 to 2025Enrolled18ConditionsAnkle OsteoarthritisArmsBMAC, HA
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Reply to the letter to the editor: comment on "No superior treatment for primary osteochondral defects of the talus".Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2017
    Article
  6. Article
  7. Osteochondral lesions of the talus in the athlete: up to date review.Current reviews in musculoskeletal medicine · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Francesca VanniniFirst Clinic of Orthopaedics and Traumatology, Rizzoli Orthopaedic Institute, Bologna, Italy.
Marco CavalloFirst Clinic of Orthopaedics and Traumatology, Rizzoli Orthopaedic Institute, Bologna, Italy.
Laura RamponiFirst Clinic of Orthopaedics and Traumatology, Rizzoli Orthopaedic Institute, Bologna, Italy.
Francesco CastagniniFirst Clinic of Orthopaedics and Traumatology, Rizzoli Orthopaedic Institute, Bologna, Italy.
Simone MassimiFirst Clinic of Orthopaedics and Traumatology, Rizzoli Orthopaedic Institute, Bologna, Italy.
Sandro GianniniBologna University, Bologna, Italy.
Roberto Emanuele BudaFirst Clinic of Orthopaedics and Traumatology, Rizzoli Orthopaedic Institute, Bologna, Italy.
Istituto Ortopedico Rizzoli · ITUniversity of Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveArthroscopic "one-step" technique based on bone marrow-derived cell transplantation (BMDCT) have achieved good results in repairing osteochondral lesions of the talus (OLT), overcoming important drawbacks of older techniques. It may be particularly adequate for the treatment of athletes in order to permit a safe and stable return to sports. The aim of this study was to report the results at 48 months of a series of athletes and the factors influencing the return to sports.

designCase series. A total of 140 athletes underwent a "one-step" BMDCT repair of OLT. All the patients had the cells harvested from the iliac crest, condensed and loaded on a scaffold, and then implanted. Patients were evaluated clinically by the American Orthopaedic Foot and Ankle Society (AOFAS) scores and Halasi score.

resultsAOFAS score improved from 58.7 ± 13.5 preoperatively to 90.6 ± 8.6 (

conclusions"One-step" BMDCT repair of OLT had good clinical results that was durable over time in athletes, permitting a return to sports at preinjury level in the majority of patients. The preoperative presence of impingement and articular degeneration were the main negative prognostic factors.

Indexed as

anklearticular cartilagecartilage repairmesenchymal stem cellssports injury

Identifiers

PMID27994723
PMCPMC5154421
OpenAlexW2339208371

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.