ReviewCartilage2017
Operative Treatment for Osteochondral Lesions of the Talus: Biologics and Scaffold-Based Therapy.
Review in Cartilage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Subchondral Bone Is Affected by Bone Marrow Stimulation: A Systematic Review of Preclinical Animal Studies.Cartilage · 2019Pooled it
- Cell Technologies in Treating Osteochondral Lesions of the Talus: A Clinical Case and Brief Review.Journal of clinical medicine · 2025Article
- Functional and radiographic outcomes of talar osteochondral lesions repaired with a combination of autologous bone graft, cell-free hyaluronic acid-based scaffold, bone marrow aspirate concentrate (BMAC) and fibrin glue.International orthopaedics · 2025Article
- Scaffolds for Osteochondral Lesions of the Talus: Systematic Review and Meta-Analysis of the Last Ten Years Literature.Bioengineering (Basel, Switzerland) · 2024Review
- Higher Accuracy of Arthroscopy Compared to MRI in the Diagnosis of Chondral Lesions in Acute Ankle Fractures: A Prospective Study.Diagnostics (Basel, Switzerland) · 2024Article
- 3D printed osteochondral scaffolds: design strategies, present applications and future perspectives.Frontiers in bioengineering and biotechnology · 2024Review
- Comparison of surface microscopy coil and ankle joint special phased array coil magnetic resonance imaging in assessing preoperative osteochondral lesions of the talus.Quantitative imaging in medicine and surgery · 2023Article
- 3D-printed gradient scaffolds for osteochondral defects: Current status and perspectives.International journal of bioprinting · 2023Review
- [Cartilage chip transplantation for cartilage defects of the first metatarsophalangeal joint].Operative Orthopadie und Traumatologie · 2021Article
- Osteochondral lesions of the talar dome: an up-to-date approach to multimodality imaging and surgical techniques.Skeletal radiology · 2021Review
- Bone marrow aspirate concentrate and scaffold for osteochondral lesions of the talus in ankle osteoarthritis: satisfactory clinical outcome at 10 years.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021Article
- High-Density Autologous Chondrocyte Implantation as Treatment for Ankle Osteochondral Defects.Cartilage · 2021Article
- One step treatment of talus osteochondral lesions with microfracture and cell free hyaluronic acid based scaffold combination.Acta orthopaedica et traumatologica turcica · 2019Article
- Lesion Size Measured on MRI Does Not Accurately Reflect Arthroscopic Measurement in Talar Osteochondral Lesions.Orthopaedic journal of sports medicine · 2019Article
- Osteochondral lesions of the talus: are we ready for metal?Annals of translational medicine · 2018Article
- Incidence of Coexisting Talar and Tibial Osteochondral Lesions Correlates With Patient Age and Lesion Location.Orthopaedic journal of sports medicine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveNumerous basic science articles have published evidence supporting the use of biologic augmentation in the treatment of osteochondral lesions of the talus (OLT). However, a comprehensive evaluation of the clinical outcomes of those treatment modalities in OLT has yet to be published. The purpose of this review is to provide an evidence-based overview of clinical outcomes following biologic augmentation to surgical treatments for OLT.
designA comprehensive literature review was performed. Two commonly used surgical techniques for the treatment of OLT-bone marrow stimulation and osteochondral autograft transfer-are first introduced. The review describes the operative indications, step-by- step operative procedure, clinical outcomes, and concerns associated with each treatment. A review of the currently published basic science and clinical evidence on biologic augmentation in the surgical treatments for OLT, including platelet-rich plasma, concentrated bone marrow aspirate, and scaffold-based therapy follows.
resultsBiologic agents and scaffold-based therapies appear to be promising agents, capable of improving both clinical and radiological outcomes in OLT. Nevertheless, variable production methods of these biologic augmentations confound the interpretation of clinical outcomes of cases treated with these agents.
conclusionsCurrent clinical evidence supports the use of biologic agents in OLT cases. Nonetheless, well-designed clinical trials with patient-specific, validated and objective outcome measurements are warranted to develop standardized clinical guidelines for the use of biologic augmentation for the treatment of OLT in clinical practice.
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