ArticleGastroenterology research2008
Cholecystectomy or Cholelithiasis - a Missed Marker for Hyperlipidaemia? A Combined Retrospective and Prospective Study.
Article in Gastroenterology research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 citing papers in PubMed, 5 citations in OpenAlex.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultiple studies have shown an association between gallstones and abnormal lipids and the latter increases the risk of coronary artery disease and stroke. Our study investigates the current incidence of lipid abnormalities in patients who have undergone cholecystectomy (retrospective study) and who have gallstones (prospective study).
methodsWe conducted a retrospective analysis of the lipid profiles of 715 patients who underwent cholecystectomy in a rural district general hospital from 2003 to 2006. Details of the cholecystectomy patients were obtained from Patient Information and Management System (PIMS) and cross-referenced with biochemical and histological databases. Following this a prospective study was undertaken of 129 patients presenting with gallstones.
resultsOf the 715 patients, three quarters were women. Only 36.2% of women and 36.9% of men who had a cholecystectomy had a full lipid profile including high density lipoproteins (HDL) and low density lipoproteins (LDL). Of these, 76.4% of women and 70.7% of men had an abnormal lipid profile. In the prospective group, 91.1 % of women and 96.3 % of men had a full lipid profile. These were abnormal in 81.4% of women and 70.4 % of men. Hypercholesterolemia and raised LDL were the most common abnormalities in both sexes. Hypertriglyceridaemia was common in both sexes in both the groups.
conclusionsPatients who have had a cholecystectomy or gallstones should have a full fasting lipid profile, including HDL and LDL, as a large proportion will be abnormal. Current guidelines suggest they are at an increased risk of cardiovascular disease and should be treated.
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