Evidence map›Paper›PMID 27994596›Full record

ArticleFrontiers in immunology2016

Cytoplasm-Translocated Ku70/80 Complex Sensing of HBV DNA Induces Hepatitis-Associated Chemokine Secretion.

Young Li, Yang Wu, Xiaohu Zheng, Jingjing Cong, Yanyan Liu, Jiabin Li, Rui Sun, Zhigang G Tian, Haiming M Wei

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
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  5. Article
  6. Review
  7. Article
  8. Review
  9. DNA double-strand break repair and nucleic acid-related immunity.Acta biochimica et biophysica Sinica · 2022
    Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. The Role of Ku70 as a Cytosolic DNA Sensor in Innate Immunity and Beyond.Frontiers in cellular and infection microbiology · 2021
    Review
  16. Review
  17. Article
  18. Cytosolic DNA Sensors and CNS Responses to Viral Pathogens.Frontiers in cellular and infection microbiology · 2020
    Review
  19. The Role of Nucleic Acid Sensing in Controlling Microbial and Autoimmune Disorders.International review of cell and molecular biology · 2019
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Young LiThe CAS Key Laboratory of Innate Immunity and Chronic Disease, Institute of Immunology, School of Life Sciences, University of Science and Technology of China, Hefei, China; University of Science and Technology of China, Hefei, China.
Yang WuThe CAS Key Laboratory of Innate Immunity and Chronic Disease, Institute of Immunology, School of Life Sciences, University of Science and Technology of China, Hefei, China; University of Science and Technology of China, Hefei, China.
Xiaohu ZhengThe CAS Key Laboratory of Innate Immunity and Chronic Disease, Institute of Immunology, School of Life Sciences, University of Science and Technology of China, Hefei, China; University of Science and Technology of China, Hefei, China.
Jingjing CongThe CAS Key Laboratory of Innate Immunity and Chronic Disease, Institute of Immunology, School of Life Sciences, University of Science and Technology of China, Hefei, China; University of Science and Technology of China, Hefei, China.
Yanyan LiuDepartment of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University , Hefei , China.
Jiabin LiDepartment of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University , Hefei , China.
Rui SunThe CAS Key Laboratory of Innate Immunity and Chronic Disease, Institute of Immunology, School of Life Sciences, University of Science and Technology of China, Hefei, China; University of Science and Technology of China, Hefei, China; Hefei National Laboratory for Physical Sciences at Microscale, Hefei, China.
Zhigang G TianThe CAS Key Laboratory of Innate Immunity and Chronic Disease, Institute of Immunology, School of Life Sciences, University of Science and Technology of China, Hefei, China; University of Science and Technology of China, Hefei, China; Hefei National Laboratory for Physical Sciences at Microscale, Hefei, China.
Haiming M WeiThe CAS Key Laboratory of Innate Immunity and Chronic Disease, Institute of Immunology, School of Life Sciences, University of Science and Technology of China, Hefei, China; University of Science and Technology of China, Hefei, China; Hefei National Laboratory for Physical Sciences at Microscale, Hefei, China.
University of Science and Technology of China · CNAnhui Medical University · CNFirst Affiliated Hospital of Anhui Medical University · CNHefei National Center for Physical Sciences at Nanoscale · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic hepatitis B virus (HBV) infection remains a serious disease, mainly due to its severe pathological consequences, which are difficult to cure using current therapies. When the immune system responds to hepatocytes experiencing rapid HBV replication, effector cells (such as HBV-specific CD8+ T cells, NK cells, NKT cells, and other subtypes of immune cells) infiltrate the liver and cause hepatitis. However, the precise recruitment of these cells remains unclear. In the present study, we found that the cytoplasm-translocated Ku70/80 complex in liver-derived cells sensed cytosolic HBV DNA and promoted hepatitis-associated chemokine secretion. Upon sensing HBV DNA, DNA-dependent protein kinase catalytic subunit and PARP1 were assembled. Then, IRF1 was activated and translocated into the nucleus, which upregulated CCL3 and CCL5 expression. Because CCR5, a major chemokine receptor for CCL3 and CCL5, is known to be critical in hepatitis B, Ku70/80 sensing of HBV DNA likely plays a critical role in immune cell recruitment in response to HBV infection.

Indexed as

chemokineDNA sensorHBVinnate immunityIRF1

Identifiers

PMID27994596
PMCPMC5136554
OpenAlexW2557330147

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.