ArticleFrontiers in neurology2016
Examining Subcortical Infarcts in the Era of Acute Multimodality CT Imaging.
Article in Frontiers in neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Where Does the Signal Go? Technical Challenges of CT Perfusion in Lacunar and Infratentorial Stroke.Tomography (Ann Arbor, Mich.) · 2026Review
- Parent Artery Disease-Related Stroke: What Is the Impact on Endovascular Treatment? A Narrative Review.Journal of clinical medicine · 2026Review
- Visualization of Culprit Perforating Artery in Subcortical Infarction Using 3D MRI and Angiography Fusion Image.Clinical neuroradiology · 2025Article
- Integrative Approaches in Acute Ischemic Stroke: From Symptom Recognition to Future Innovations.Biomedicines · 2023Review
- Perfusion Status in Lacunar Stroke: A Pathophysiological Issue.Diagnostics (Basel, Switzerland) · 2023Review
- CT Perfusion in Lacunar Stroke: A Systematic Review.Diagnostics (Basel, Switzerland) · 2023Review
- Advances in differential diagnosis of cerebrovascular diseases in magnetic resonance imaging: a narrative review.Quantitative imaging in medicine and surgery · 2023Review
- Computed tomography perfusion imaging-guided intravenous thrombolysis in acute minor ischemic stroke.Frontiers in neurology · 2023Article
- Neuroimaging investigation of the intracranial vasculature is warranted in older adults with lacunes of presumed vascular origin.The neuroradiology journal · 2022Article
- The Potential Impact of Neuroimaging and Translational Research on the Clinical Management of Lacunar Stroke.International journal of molecular sciences · 2022Review
- Magnetic resonance imaging assessment of cerebral small vessel disease intensification in patients with severe aortic valve stenosis.Polish journal of radiology · 2021Article
- Circular RNAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Pathophysiology of Lacunar Stroke: History's Mysteries and Modern Interpretations.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2019Review
- Cerebral perfusion and compensatory blood supply in patients with recent small subcortical infarcts.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Advances in Understanding the Pathophysiology of Lacunar Stroke: A Review.JAMA neurology · 2018Review
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLacunar infarct has been characterized as small subcortical infarct. It is postulated to occur from " MATERIALS AND
methodsPatients undergoing acute CT perfusion/angiography (CTP/CTA) within 6 h of symptom onset and follow-up magnetic resonance imaging (MRI) for ischemic stroke were included (2009-2013). Lacunar infarct was defined as a single subcortical infarct ≤20 mm on follow-up MRI. Presence of perfusion deficits, vessel occlusion, and infarct dimensions was compared between lacunar infarcts and other topographical infarct types.
resultsOverall, 182 patients (mean age 66.4 ± 15.3 years, 66% males) were included. Lacunar infarct occurred in 31 (17%) patients. Of these, 12 (39%) patients had a perfusion deficit compared with those with any cortical infarction (120/142, 67%), and the smallest lacunar infarct with a perfusion deficit had a diameter of <5 mm. The majority of patients with lacunar infarction (8/12, 66.7%) had a relevant vessel occlusion. A quarter of lacunar infarcts had a large artery stroke mechanism evident on acute CTP/CTA. Lacunar mechanism was present in 3/8 patients with corona radiata, 5/10 lentiform nucleus, 5/6 posterior limb of internal capsule (PLIC), 3/5 thalamic infarcts, 1/2 miscellaneous locations. There was a trend to significant with regards to finding lacunar mechanism among patients with thalamic and PLIC infarcts versus lentiform nucleus and corona radiata infarcts (
conclusionDiverse stroke mechanisms were present among subcortical infarcts in different locations. When available acute CTP/CTA should be combined with subacute imaging of subcortical infarct to separate "lacunar phenotype" from those with lacunar mechanism.
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