ArticleTransfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie2016
Anti-D Antibodies in Pregnant D Variant Antigen Carriers Initially Typed as RhD.
Article in Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Misclassification of RhD variants among pregnant women: a systematic review.Journal of medicine and life · 2023Pooled it
- Article
- Hemolytic disease of the fetus and newborn-a perspective of immunohematology.Hematology, transfusion and cell therapy · 2024Review
- Transfusion support for a woman withImmunohematology · 2022Article
- Proceed with care: the "uncommon" serologic weak D phenotypes.Blood transfusion = Trasfusione del sangue · 2021Article
- Anti-D reagents should be chosen accordingly to the prevalence of D variants in the obstetric population.Journal of clinical laboratory analysis · 2018Article
- Serological weak D phenotypes: a review and guidance for interpreting the RhD blood type using the RHD genotype.British journal of haematology · 2017Review
- Complete D epitope expression of the most common weak D types 15, 25, 33, and 72 in the Chinese population.Blood transfusion = Trasfusione del sangueArticle
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo evaluate the incidence, the consequences, and the prevention strategy of anti-D alloimmunizations of D variant carriers in the obstetric population of Split-Dalmatia County, Croatia.
methodsRhD immunization events were evaluated retrospectively for the period between 1993 and 2012. Women were tested for RhD antigen and irregular antibodies. Those with anti-D antibody who were not serologically D- were genotyped for RHD. They were evaluated for their obstetric and transfusion history and their titer of anti-D. The neonates were evaluated for RhD status, direct antiglobulin test (DAT), hemoglobin and bilirubin levels, transfusion therapy as well as phototherapy and outcome.
resultsOut of 104,884 live births 102,982 women were tested for RhD antigen. Anti-D immunization occurred in 184 women which accounts for 0.9% of individuals at risk of anti-D formation. 181 cases occurred in women serologically typed as D-. Three women were partial D carriers (DVa n = 2, DNB n = 1), initially typed RhD+, and recognized as D variant carriers after the immunization occurred. Anti-D titer varied from 1:1 to 1:16. Six children were RhD+, four had positive DAT, and two underwent phototherapy.
conclusionAnti-D immunization occurred in pregnant partial D carriers (DVa, DNB). RhD+ children had serologic markers of hemolytic disease of the fetus and newborn (HDFN), with no cases of severe HDFN.
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