Evidence map›Paper›PMID 27994508›Full record

ReviewInternational journal of biological sciences2016

CRISPR-Cas9: from Genome Editing to Cancer Research.

Si Chen, Heng Sun, Kai Miao, Chu-Xia Deng

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
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  10. Article
  11. Animal models of cholangiocarcinoma.Biochimica et biophysica acta. Molecular basis of disease · 2019
    Review
  12. Article
  13. World journal of gastroenterology · 2018
    Article
  14. Article
  15. Review
  16. Physiological Roles and Therapeutic Potential of CaFrontiers in molecular neuroscience · 2018
    Review
  17. Article
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Si ChenFaculty of Health Sciences, University of Macau, Macau SAR, China.
Heng SunFaculty of Health Sciences, University of Macau, Macau SAR, China.
Kai MiaoFaculty of Health Sciences, University of Macau, Macau SAR, China.
Chu-Xia DengFaculty of Health Sciences, University of Macau, Macau SAR, China.
University of Macau · MO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer development is a multistep process triggered by innate and acquired mutations, which cause the functional abnormality and determine the initiation and progression of tumorigenesis. Gene editing is a widely used engineering tool for generating mutations that enhance tumorigenesis. The recent developed clustered regularly interspaced short palindromic repeats-CRISPR-associated 9 (CRISPR-Cas9) system renews the genome editing approach into a more convenient and efficient way. By rapidly introducing genetic modifications in cell lines, organs and animals, CRISPR-Cas9 system extends the gene editing into whole genome screening, both in loss-of-function and gain-of-function manners. Meanwhile, the system accelerates the establishment of animal cancer models, promoting

Indexed as

AnimalsCRISPR-Cas SystemsDisease Models, AnimalDNAGene EditingHumansNeoplasmsDNAanimal model.cancerCRISPRgenome editinglarge-scale screening

Identifiers

PMID27994508
PMCPMC5166485
OpenAlexW2563770935

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.