Evidence map›Paper›PMID 27994462›Full record

ArticleInternational journal of nanomedicine

Novel guanidinylated bioresponsive poly(amidoamine)s designed for short hairpin RNA delivery.

Jiankun Yu, Jinmin Zhang, Haonan Xing, Yanping Sun, Zhen Yang, Tianzhi Yang, Cuifang Cai, Xiaoyun Zhao, Li Yang, Pingtian Ding

Abstract read
In one paragraph

Article in International journal of nanomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiankun YuSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China.
Jinmin ZhangSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China.
Haonan XingSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China.
Yanping SunSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China.
Zhen YangSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China.
Tianzhi YangDepartment of Basic Pharmaceutical Sciences, School of Pharmacy, Husson University, Bangor, ME, USA.
Cuifang CaiSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China.
Xiaoyun ZhaoDepartment of Microbiology and Cell Biology, School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China.
Li YangSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China.
Pingtian DingSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Two different disulfide (SS)-containing poly(amidoamine) (PAA) polymers were constructed using guanidino (Gua)-containing monomers (ie, arginine [Arg] and agmatine [Agm]) and

Indexed as

Cell SurvivalDNAFanconi Anemia Complementation Group E ProteinHumansMCF-7 CellsMicroscopy, Atomic ForceParticle SizePlasmidsPolyaminesPolyethyleneiminePolymerizationPolymersRNA, Small InterferingTransfectionDNAFANCE protein, humanFanconi Anemia Complementation Group E ProteinPoly(amidoamine)PolyaminesPolyethyleneiminePolymersRNA, Small Interferingbioresponsivecytotoxicitygene carrierguanidinylated disulfide-containing poly(amido amine)nuclear localizationshort hairpin RNAtransfection efficiency

Identifiers

PMID27994462
PMCPMC5154728

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.