ArticleAnnals of Indian Academy of Neurology
CD6 gene polymorphism rs17824933 is associated with multiple sclerosis in Indian population.
Article in Annals of Indian Academy of Neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Identification of a novel genetic locus associated with immune-mediated thrombotic thrombocytopenic purpura.Haematologica · 2022Pooled it
- Soluble CD72, is a T-cell activator probably via binding to CD6 in homeostasis and autoimmunity.Frontiers in immunology · 2024Article
- Analysis of herpesvirus infection and genome single nucleotide polymorphism risk factors in multiple sclerosis, Volga federal district, Russia.Frontiers in immunology · 2022Article
- Preliminary Study on the Role of TMEM39A Gene in Multiple Sclerosis.Journal of molecular neuroscience : MN · 2017Article
- Multiple Sclerosis in India.Annals of Indian Academy of NeurologyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultiple sclerosis (MS) prevalence has increased worldwide. The known genetic association for MS in the west has not been studied in detail in nonwhite populations and particularly Indians.
objectiveThe objective of this study was to evaluate some known genetic variations outside the major histocompatibility complex (MHC) region associated with MS in patients of Indian origin. MATERIALS AND
methodsWe investigated 10 gene-associated single nucleotide polymorphisms (SNP's) outside the MHC region in 300 patients and 720 unrelated controls. Genotyping was performed on an ABI7500 real-time polymerase chain reaction genotyping platform using predesigned TaqMan SNP genotyping assays.
resultsCD6 gene associated SNP (rs17824933) showed significant association with MS (
conclusionOur data illustrate the similarity in risk association between Indian and European populations for MS.
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Registered trials
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