ArticleProceedings of the National Academy of Sciences of the United States of America2016
One Health approach to cost-effective rabies control in India.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- Comprehensive league table of cost-utility ratios: A systematic review of cost-effectiveness evidence for health policy decisions in India.Frontiers in public health · 2022Pooled it
- Evaluating the role of surgical sterilisation in canine rabies control: A systematic review of impact and outcomes.PLoS neglected tropical diseases · 2020Pooled it
- Serological response to field rabies vaccination in owned dogs in the immune belt of Peninsular Malaysia.Veterinary research communications · 2026Article
- Strengthening animal rabies surveillance through a public-private One Health collaboration: Insights from a field veterinarian workshop in Assam, India.One health (Amsterdam, Netherlands) · 2026Article
- Towards "Zero by 30", the Kenyan case: a systematic exploration of barriers to rabies policy implementation through systems thinking.Health research policy and systems · 2025Article
- Assessing Health System preparedness for dog mediated rabies in South-East Asia Region.Journal of preventive medicine and hygiene · 2025Review
- Epidemiological insights into canine rabies in Chennai: Trends, forecasting and One Health implications.One health (Amsterdam, Netherlands) · 2025Article
- Disparities in Global Rabies Burden from GBD 2021: Children, older adults, and low-SDI countries at continued risk.PLoS neglected tropical diseases · 2025Article
- The Economic Landscape of Global Rabies: A Scoping Review and Future Directions.Tropical medicine and infectious disease · 2025Review
- The application of the One Health approach in the management of five major zoonotic diseases using the World Bank domains: A scoping review.One health (Amsterdam, Netherlands) · 2024Article
- Rabies death in an adolescent tribal girl diagnosed postmortem, in Kerala - the precious life, preventable loss and equity concerns.International journal for equity in health · 2024Article
- Global Mapping and Visualization Analysis of One Health Knowledge in the COVID-19 Context.Environmental health insights · 2024Article
- Review
- Optimising rabies vaccination of dogs in India.Epidemiology and infection · 2023Article
- Strategies to inTerrupt RAbies Transmission for the Elimination Goal by 2030 In China (STRATEGIC): a modelling study.BMC medicine · 2023Article
- One Health responses to prevent the occurrence of rabies due to attacks by a rabid stray dog.Veterinary medicine and science · 2023Article
- One Health activities to reinforce intersectoral coordination at local levels in India.Frontiers in public health · 2023Review
- Rabies Outbreak in the Urban Area of Delhi: An Investigation Report and One Health Perspective for Outbreak Management.Infectious disease reports · 2022Article
- Assessing the impact of free-roaming dog population management through systems modelling.Scientific reports · 2022Article
- Elimination of human rabies in Goa, India through an integrated One Health approach.Nature communications · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 3 countries.
Funding
Abstract
Over 20,000 rabies deaths occur annually in India, representing one-third of global human rabies. The Indian state of Tamil Nadu has pioneered a "One Health" committee to address the challenge of rabies in dogs and humans. Currently, rabies control in Tamil Nadu involves postexposure vaccination of humans after dog bites, whereas potential supplemental approaches include canine vaccination and sterilization. We developed a data-driven rabies transmission model fit to human rabies autopsy data and human rabies surveillance data from Tamil Nadu. Integrating local estimates for canine demography and costs, we predicted the impact of canine vaccination and sterilization on human health outcomes and evaluated cost-effectiveness according to the WHO criteria for India, which correspond to thresholds of $1,582 and $4,746 per disability-adjusted life-years (DALYs) for very cost-effective and cost-effective strategies, respectively. We found that highly feasible strategies focused on stray dogs, vaccinating as few as 7% of dogs annually, could very cost-effectively reduce human rabies deaths by 70% within 5 y, and a modest expansion to vaccinating 13% of stray dogs could cost-effectively reduce human rabies by almost 90%. Through integration over parameter uncertainty, we find that, for a cost-effectiveness threshold above $1,400 per DALY, canine interventions are at least 95% likely to be optimal. If owners are willing to bring dogs to central point campaigns at double the rate that campaign teams can capture strays, expanded annual targets become cost-effective. This case study of cost-effective canine interventions in Tamil Nadu may have applicability to other settings in India and beyond.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.