ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2017
The origins, scaling and loss of tetrapod digits.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Development of whole-limb skeletal patterning through the coordination of growth and self-organization models.PLoS computational biology · 2026Article
- Dual Bmp-negative feedback loops modulate function of both AER and ZPA to buffer and constrain postaxial digit number.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Adaptive evolution ofZoological research · 2025Article
- Article
- Morphogens in the evolution of size, shape and patterning.Development (Cambridge, England) · 2024Review
- Mammalian forelimb evolution is driven by uneven proximal-to-distal morphological diversity.eLife · 2023Article
- The cellular basis of cartilage growth and shape change in larval and metamorphosing Xenopus frogs.PloS one · 2023Article
- Non-model systems in mammalian forelimb evo-devo.Current opinion in genetics & development · 2021Review
- Repeated loss of variation in insect ovary morphology highlights the role of development in life-history evolution.Proceedings. Biological sciences · 2021Article
- Pentadactyl manus of the Metoposaurus krasiejowensis from the Late Triassic of Poland, the first record of pentadactyly among Temnospondyli.Journal of anatomy · 2020Article
- A dot-stripe Turing model of joint patterning in the tetrapod limb.Development (Cambridge, England) · 2020Article
- Evidence of five digits in embryonic horses and developmental stabilization of tetrapod digit number.Proceedings. Biological sciences · 2020Article
- Review
- Evolution of antero-posterior patterning of the limb: Insights from the chick.Genesis (New York, N.Y. : 2000) · 2018Review
- Mechanics of evolutionary digit reduction in fossil horses (Equidae).Proceedings. Biological sciences · 2017Article
- Perspectives on the history of evo-devo and the contemporary research landscape in the genomics era.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Many of the great morphologists of the nineteenth century marvelled at similarities between the limbs of diverse species, and Charles Darwin noted these homologies as significant supporting evidence for descent with modification from a common ancestor. Sir Richard Owen also took great care to highlight each of the elements of the forelimb and hindlimb in a multitude of species with focused attention on the homology between the hoof of the horse and the middle digit of man. The ensuing decades brought about a convergence of palaeontology, experimental embryology and molecular biology to lend further support to the homologies of tetrapod limbs and their developmental origins. However, for all that we now understand about the conserved mechanisms of limb development and the development of gross morphological disturbances, little of what is presented in the experimental or medical literature reflects the remarkable diversity resulting from the 450 million year experiment of natural selection. An understanding of conserved and divergent limb morphologies in this new age of genomics and genome engineering promises to reveal more of the developmental potential residing in all limbs and to unravel the mechanisms of evolutionary variation in limb size and shape. In this review, we present the current state of our rapidly advancing understanding of the evolutionary origin of hands and feet and highlight what is known about the mechanisms that shape diverse limbs.This article is part of the themed issue 'Evo-devo in the genomics era, and the origins of morphological diversity'.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.