ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2017
Deep homology in the age of next-generation sequencing.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- Little Known Facts, Controversies and Misconceptions About Cranial Motor Nuclei (and a New Classification for All Motoneurons, Cranial, and Spinal).The Journal of comparative neurology · 2026Review
- Proximal phalanges of digit 1 have different identities in the forelimbs and hindlimbs of the mouse.Scientific reports · 2025Article
- Asymmetric development and function of paired sperm-storage organs inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Distinct gene regulatory dynamics drive skeletogenic cell fate convergence during vertebrate embryogenesis.Nature communications · 2025Article
- Molecular basis of urostyle development in frogs: genes and gene regulation underlying an evolutionary novelty.Open biology · 2024Article
- Rebuilding ships while at sea-Character individuality, homology, and evolutionary innovation.Journal of morphology · 2023Article
- Assessing evolutionary and developmental transcriptome dynamics in homologous cell types.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- Cancer genes and cancer stem cells in tumorigenesis: Evolutionary deep homology and controversies.Genes & diseases · 2022Review
- Does integument ariseFrontiers in plant science · 2022Article
- Extracellular matrix gene expression signatures as cell type and cell state identifiers.Matrix biology plus · 2021Article
- Article
- Cellular transcriptomics reveals evolutionary identities of songbird vocal circuits.Science (New York, N.Y.) · 2021Article
- Animal models built for women's brain health: Progress and potential.Frontiers in neuroendocrinology · 2020Review
- A single-cell transcriptomic atlas of the developing chicken limb.BMC genomics · 2019Article
- Cross-Species Analysis of Single-Cell Transcriptomic Data.Frontiers in cell and developmental biology · 2019Article
- Transcription factor DUO1 generated by neo-functionalization is associated with evolution of sperm differentiation in plants.Nature communications · 2018Article
- Rethinking Living Fossils.Bioscience · 2018Article
- Phenotypic Convergence: Distinct Transcription Factors Regulate Common Terminal Features.Cell · 2018Article
- Perspectives on the history of evo-devo and the contemporary research landscape in the genomics era.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
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2 authors.
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Abstract
The principle of homology is central to conceptualizing the comparative aspects of morphological evolution. The distinctions between homologous or non-homologous structures have become blurred, however, as modern evolutionary developmental biology (evo-devo) has shown that novel features often result from modification of pre-existing developmental modules, rather than arising completely de novo. With this realization in mind, the term 'deep homology' was coined, in recognition of the remarkably conserved gene expression during the development of certain animal structures that would not be considered homologous by previous strict definitions. At its core, it can help to formulate an understanding of deeper layers of ontogenetic conservation for anatomical features that lack any clear phylogenetic continuity. Here, we review deep homology and related concepts in the context of a gene expression-based homology discussion. We then focus on how these conceptual frameworks have profited from the recent rise of high-throughput next-generation sequencing. These techniques have greatly expanded the range of organisms amenable to such studies. Moreover, they helped to elevate the traditional gene-by-gene comparison to a transcriptome-wide level. We will end with an outlook on the next challenges in the field and how technological advances might provide exciting new strategies to tackle these questions.This article is part of the themed issue 'Evo-devo in the genomics era, and the origins of morphological diversity'.
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