ArticleThe Journal of experimental medicine2017
Intrinsic transcriptional heterogeneity in B cells controls early class switching to IgE.
Article in The Journal of experimental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 58 citations in OpenAlex.
- Competing gene regulatory networks drive naive and memory B cell differentiation.Molecular systems biology · 2026Article
- GATHeR: graph-based accurate tool for immunoglobulin heavy- and light-chain reconstruction.Nature communications · 2026Article
- The impact of potential food allergen exposure on wound healing after malignant tumor surgery: immune tolerance alterations and clinical risk assessment.Frontiers in immunology · 2026Review
- Lung-resident memory B cells maintain allergic IgE responses in the respiratory tract.Immunity · 2025Article
- The single-cell transcriptional landscape of lung cells from PCV2d-infected mice.Frontiers in microbiology · 2025Article
- Engrafted NSG-SGM3 humanized mice spontaneously produce human immunoglobulins including IgE.Frontiers in immunology · 2025Article
- TSLPR deficiency attenuates AHR independently of eosinophilia and mucus secretion in a chronic HDM mouse model of allergic asthma.PloS one · 2025Article
- T follicular regulatory cells in food allergy promote IgE via IL-4.JCI insight · 2024Article
- sciCSR infers B cell state transition and predicts class-switch recombination dynamics using single-cell transcriptomic data.Nature methods · 2024Article
- Single-cell profiling of African swine fever virus disease in the pig spleen reveals viral and host dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Comparison of Non B-Ig and B-Ig.Advances in experimental medicine and biology · 2024Review
- Lineage tracing reveals fate bias and transcriptional memory in human B cells.Life science alliance · 2023Article
- Progress in Discovering Transcriptional Noise in Aging.International journal of molecular sciences · 2023Review
- B cells defined by immunoglobulin isotypes.Clinical and experimental immunology · 2022Article
- Induction of natural IgE by glucocorticoids.The Journal of experimental medicine · 2022Article
- Development of allergen-specific IgE in a food-allergy model requires precisely timed B cell stimulation and is inhibited by Fgl2.Cell reports · 2022Article
- Editorial: Transcriptional Regulation in Metabolism and Immunology.Frontiers in genetics · 2022Article
- Switch Tandem Repeats Influence the Choice of the Alternative End-Joining Pathway in Immunoglobulin Class Switch Recombination.Frontiers in immunology · 2022Article
- Loop extrusion promotes an alternate pathway for isotype switching.Cell reports · 2021Article
- Deletion of IL-4Rα signaling on B cells limits hyperresponsiveness depending on antigen load.The Journal of allergy and clinical immunology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Noncoding transcripts originating upstream of the immunoglobulin constant region (I transcripts) are required to direct activation-induced deaminase to initiate class switching in B cells. Differential regulation of Iε and Iγ1 transcription in response to interleukin 4 (IL-4), hence class switching to IgE and IgG1, is not fully understood. In this study, we combine novel mouse reporters and single-cell RNA sequencing to reveal the heterogeneity in IL-4-induced I transcription. We identify an early population of cells expressing Iε but not Iγ1 and demonstrate that early Iε transcription leads to switching to IgE and occurs at lower activation levels than Iγ1. Our results reveal how probabilistic transcription with a lower activation threshold for Iε directs the early choice of IgE versus IgG1, a key physiological response against parasitic infestations and a mediator of allergy and asthma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.