ArticleThe Journal of experimental medicine2017
Resetting microbiota by Lactobacillus reuteri inhibits T reg deficiency-induced autoimmunity via adenosine A2A receptors.
2 registry-linked trialsOpen access · bronzeAbstract read
In one paragraph
Article in The Journal of experimental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 117 papers.
0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed
9.3field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Can Individualized Diet and Lifestyle Modifications Derived From Digital Therapeutics and Health Coaching Improve Symptoms of Systemic Lupus Erythematosus
Rewilding the Human Gut: Reintroduction of the Species Limosilactobacillus Reuteri
Who cites it
117 citing papers in PubMed, 195 citations in OpenAlex.
- Trial
- Effects of Short-Term Dietary Fiber Intervention on Gut Microbiota in Young Healthy People.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Trial
- Health-Related Quality of Life Improvements in Systemic Lupus Erythematosus Derived from a Digital Therapeutic Plus Tele-Health Coaching Intervention: Randomized Controlled Pilot Trial.Journal of medical Internet research · 2020Trial
- Article
- Glutamine-dependent biosynthetic pathways fuel autoreactive T and B cells in Foxp3 deficiency-mediated disease.JCI insight · 2026Article
- From Gut Homeostasis to Colorectal Cancer: Spatial and Temporal Reprogramming of Microbial Inosine Signaling.Biomedicines · 2026Review
- Limosilactobacillus reuteri Strains Differentially Stimulate Immunity in Response to Human Milk Oligosaccharides in Newborn Mice.Probiotics and antimicrobial proteins · 2026Article
- Article
- The relationship between gut microbiota and cancer immune response and immunotherapy.Frontiers in immunology · 2026Review
- Genome characterization and comparative genomics ofFrontiers in microbiology · 2026Article
- Targeting LRBA triggers CTLA4 degradation and antitumor immunity for cancer immunotherapy.Nature communications · 2025Article
- Lactobacillus reuteri postbiotics improved growth performance and intestinal health of broilers with necrotic enteritis.BMC veterinary research · 2025Article
- Review
- Microbiota-dependent metabolites - New engine for T cell warriors.Gut microbes · 2025Review
- Protective Effects of Aucubin in DSS-Induced Colitis: Modulation of Inflammatory Pathways, Intestinal Barrier Integrity, and Gut Microbiota.Foods (Basel, Switzerland) · 2025Article
- Microbial metabolite facilitates virus control: inosine and T cells curb early-life influenza infection.Signal transduction and targeted therapy · 2025Article
- Integrating neuroscience and oncology: neuroimmune crosstalk in the initiation and progression of digestive system tumors.Molecular cancer · 2025Review
- The tumor microbiome in cancer progression: mechanisms and therapeutic potential.Molecular cancer · 2025Review
- Designing live bacterial therapeutics for cancer.Advanced drug delivery reviews · 2025Review
- Impact of gut microbiota on colorectal anastomotic healing (Review).Molecular and clinical oncology · 2025Review
57 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 4 institutions in 2 countries.
Baokun HePediatrics Gastroenterology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX 77030.ORCID 0000-0002-8808-1997
Thomas K HoangPediatrics Gastroenterology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX 77030.
Ting WangPediatrics Gastroenterology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX 77030.ORCID 0000-0003-2222-5211
Michael FerrisDepartment of Microbiology, Immunology and Parasitology, Louisiana State University School of Medicine, New Orleans, LA 70118.ORCID 0000-0003-0473-7440
Christopher M TaylorDepartment of Microbiology, Immunology and Parasitology, Louisiana State University School of Medicine, New Orleans, LA 70118.ORCID 0000-0002-7983-5275
Xiangjun TianThe Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030.
Meng LuoDepartment of Microbiology, Immunology and Parasitology, Louisiana State University School of Medicine, New Orleans, LA 70118.
Dat Q TranPediatric Research Center, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX 77030.ORCID 0000-0001-5310-8849
Jain ZhouPathology and Laboratory Medicine, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX 77030.
Nina TatevianPathology and Laboratory Medicine, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX 77030.
Fayong LuoDepartment of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX 77030.ORCID 0000-0001-8398-8197
Jose G MolinaDepartment of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX 77030.
Michael R BlackburnDepartment of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX 77030.
Thomas H GomezCenter for Laboratory Animal Medicine and Care, The University of Texas Health Science Center at Houston, Houston, TX 77030.
Stefan RoosDepartment of Microbiology, Uppsala BioCenter, Swedish University of Agricultural Sciences, 750 07 Uppsala, Sweden.ORCID 0000-0002-1606-1794
J Marc RhoadsPediatrics Gastroenterology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX 77030 Yuying.Liu@uth.tmc.edu J.Marc.Rhoads@uth.tmc.edu.ORCID 0000-0002-6252-9490
Yuying LiuPediatrics Gastroenterology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX 77030 Yuying.Liu@uth.tmc.edu J.Marc.Rhoads@uth.tmc.edu.ORCID 0000-0003-3848-9254
The University of Texas Health Science Center at Houston · USLouisiana State University · USBaylor College of Medicine · USSwedish University of Agricultural Sciences · SE
Funding
Trangenic Mouse Breeding CoreP01HL114457 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BLACKBURN, MICHAEL R · 2013 to 2017
$10.0MStability and potency of LAP+FOXP3+Tregs as novel cell therapy for GVHDR01HL113304 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI TRAN, DAT QUOC · 2012 to 2016
$1.9MMechanisms of L. reuteri in regulating intestinal inflammationR01AT007083 · NCCIH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LIU, YUYING, RHOADS, JON MARC · 2014 to 2018
$1.7MLactobacillus reuteri treatment for Treg-deficiency Autoimmune DiseaseR03AI117442 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LIU, YUYING · 2015 to 2016
$160kNCCIH NIH HHS R01 AT007083NHLBI NIH HHS P01 HL114457NHLBI NIH HHS R01 HL113304NIAID NIH HHS R03 AI117442
Abstract
Regulatory T (T reg) cell deficiency causes lethal, CD4
Indexed as
AutoimmunityGastrointestinal MicrobiomeLimosilactobacillus reuteriAnimalsCell DifferentiationFemaleInosineMaleMetabolomicsMiceMice, Inbred C57BLReceptor, Adenosine A2ATh1 CellsTh2 CellsT-Lymphocytes, RegulatoryInosineReceptor, Adenosine A2A
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390
Registered trials
NCT03426384ClinicalTrials.gov
NCT03501082ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.