ArticleThe Journal of biological chemistry2017
Assessing Oxidative Stress in Tumors by Measuring the Rate of Hyperpolarized [1-13C]Dehydroascorbic Acid Reduction Using 13C Magnetic Resonance Spectroscopy.
Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Hyperpolarised magnetic resonance spectroscopy with lab-on-a-chip disease models.Disease models & mechanisms · 2026Review
- Cell-intrinsic metabolic phenotypes identified in patients with glioblastoma, using mass spectrometry imaging ofNature metabolism · 2025Article
- Quo Vadis HyperpolarizedZeitschrift fur medizinische Physik · 2025Review
- Detecting biomarkers by dynamic nuclear polarization enhanced magnetic resonance.National science review · 2024Review
- Dihydroartemisinin inhibits liver cancer cell migration and invasion by reducing ATP synthase production through CaMKK2/NCLX.Oncology letters · 2023Article
- Imaging Techniques in Pharmacological Precision Medicine.Handbook of experimental pharmacology · 2023Article
- Latest Advances in Imaging Oxidative Stress in Cancer.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021Review
- Real-Time insight into in vivo redox status utilizing hyperpolarized [1-Scientific reports · 2021Article
- Challenges and Advances in the Application of Dynamic Nuclear Polarization to Liquid-State NMR Spectroscopy.The journal of physical chemistry. B · 2021Review
- PET Imaging for Oxidative Stress in Neurodegenerative Disorders Associated with Mitochondrial Dysfunction.Antioxidants (Basel, Switzerland) · 2020Review
- Imaging Brain Metabolism Using HyperpolarizedTrends in neurosciences · 2020Review
- In vivo detection of γ-glutamyl-transferase up-regulation in glioma using hyperpolarized γ-glutamyl-[1-Scientific reports · 2020Article
- Probing carbohydrate metabolism using hyperpolarizedNMR in biomedicine · 2019Review
- Oxidation of Human Copper Chaperone Atox1 and Disulfide Bond Cleavage by Cisplatin and Glutathione.International journal of molecular sciences · 2019Article
- Assessing the effect of hypoxia on cardiac metabolism using hyperpolarizedNMR in biomedicine · 2019Article
- In vivo investigation of hyperpolarized [1,3-Scientific reports · 2019Article
- HyperpolarizedNeoplasia (New York, N.Y.) · 2019Review
- Metabolic and Molecular Imaging with Hyperpolarised Tracers.Molecular imaging and biology · 2018Review
- Theranostics and metabolotheranostics for precision medicine in oncology.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2018Review
- Imaging glutathione depletion in the rat brain using ascorbate-derived hyperpolarized MR and PET probes.Scientific reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Rapid cancer cell proliferation promotes the production of reducing equivalents, which counteract the effects of relatively high levels of reactive oxygen species. Reactive oxygen species levels increase in response to chemotherapy and cell death, whereas an increase in antioxidant capacity can confer resistance to chemotherapy and is associated with an aggressive tumor phenotype. The pentose phosphate pathway is a major site of NADPH production in the cell, which is used to maintain the main intracellular antioxidant, glutathione, in its reduced state. Previous studies have shown that the rate of hyperpolarized [1-
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.