Evidence map›Paper›PMID 27994055›Full record

ArticleThe Journal of biological chemistry2017

SMAD3 Regulates Follicle-stimulating Hormone Synthesis by Pituitary Gonadotrope Cells

Yining Li, Gauthier Schang, Ulrich Boehm, Chu-Xia Deng, Jonathan Graff, Daniel J Bernard

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Article
  5. Review
  6. Characterization of Forkhead Box Transcription Factor (Animals : an open access journal from MDPI · 2026
    Article
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  12. Review
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  20. A First Insight into the Gonad Transcriptome of Hong Kong Catfish (Animals : an open access journal from MDPI · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 4 countries.

Yining LiFrom the Centre for Research in Reproduction and Development, Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3G 1Y6, Canada.
Gauthier SchangFrom the Centre for Research in Reproduction and Development, Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3G 1Y6, Canada.
Ulrich Boehmthe Department of Pharmacology and Toxicology, University of Saarland School of Medicine, D-66421 Homburg, Germany.
Chu-Xia Dengthe Faculty of Health Sciences, University of Macau, Macau SAR 999078, China, and.
Jonathan Graffthe Department of Developmental Biology, University of Texas Southwestern, Dallas, Texas 75390.
Daniel J BernardFrom the Centre for Research in Reproduction and Development, Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3G 1Y6, Canada, daniel.bernard@mcgill.ca.
McGill University · CASaarland University · DEThe University of Texas Southwestern Medical Center · USUniversity of Macau · MO

Funding

Testosterone-GnRH Frequency and the Evolution of PCOS in AdolescenceP50HD028934 · NICHD · UNIVERSITY OF VIRGINIA · PI HAISENLEDER, DANIEL J. · 2014 to 2018
$8.6M
CIHR MOP-133394NICHD NIH HHS P50 HD028934
6 · The paper itself

Abstract

Pituitary follicle-stimulating hormone (FSH) is an essential regulator of fertility in females and of quantitatively normal spermatogenesis in males. Pituitary-derived activins are thought to act as major stimulators of FSH synthesis by gonadotrope cells.

Indexed as

AnimalsExonsFemaleFollicle Stimulating HormoneGonadotrophsInfertility, FemaleInfertility, MaleMaleMiceMice, KnockoutSmad3 ProteinSmad4 ProteinSpermatogenesisFollicle Stimulating HormoneSmad3 ProteinSmad3 protein, mouseSmad4 ProteinSmad4 protein, mouseactivinfollicle-stimulating hormone (FSH)gene knock-outpituitary glandSMAD transcription factor

Identifiers

PMID27994055
PMCPMC5313102
OpenAlexW2564640374

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.