ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2017
Associations of Brain Structure With Adiposity and Changes in Adiposity in a Middle-Aged and Older Biracial Population.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Associations of clinical obesity with arterial stiffness and cerebral small vessel disease: a population-based study.Frontiers in endocrinology · 2026Article
- Racial and ethnic differences in cardiometabolic predictors of white matter hyperintensities burden among males: The HABS-HD study.Journal of Alzheimer's disease : JAD · 2025Article
- Neurometabolic Profile in Obese Patients: A Cerebral Multi-Voxel Magnetic Resonance Spectroscopy Study.Medicina (Kaunas, Lithuania) · 2024Article
- Associations between adiposity and white matter hyperintensities: Cross-sectional and longitudinal analyses of 34,653 participants.Human brain mapping · 2024Article
- Article
- Mediation effects of diabetes and inflammation on the relationship of obesity to cognitive impairment in African Americans.Journal of the American Geriatrics Society · 2022Review
- Association of life course adiposity with risk of incident dementia: a prospective cohort study of 322,336 participants.Molecular psychiatry · 2022Article
- Obesity as a Risk Factor for Accelerated Brain Ageing in First-Episode Psychosis-A Longitudinal Study.Schizophrenia bulletin · 2021Article
- Imaging-based indices of Neuropathology and gait speed decline in older adults: the atherosclerosis risk in communities study.Brain imaging and behavior · 2021Article
- Measures of obesity are associated with MRI markers of brain aging: The Northern Manhattan Study.Neurology · 2019Article
- Lifestyle Risk Factors and Findings on Brain Magnetic Resonance Imaging of Older Adult American Indians: The Strong Heart Study.Neuroepidemiology · 2019Article
- Cardiorespiratory fitness attenuates age-associated aggregation of white matter hyperintensities in an at-risk cohort.Alzheimer's research & therapy · 2018Article
- Accumulating Data to Optimally Predict Obesity Treatment (ADOPT): Recommendations from the Biological Domain.Obesity (Silver Spring, Md.) · 2018Article
- Relationships of Clinical and Computed Tomography-Imaged Adiposity with Cognition in Middle-Aged and Older African Americans.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundStudies of adiposity and brain pathology in African Americans (AA) are sparse despite higher rates of obesity, dementia, and dementia-associated brain pathology in AA. This study examined relations of adiposity to white matter hyperintensities (WMH) and total brain volume (TBV) in AA and non-Hispanic whites (NHW).
methodsWaist circumference (WC) and body mass index (BMI) were measured in the Genetic Epidemiology Network of Arteriopathy study at Visits 1 (mean age 57 [±11]) and 2 (mean age 61 [±10], mean 5.2 years later). Brain MRIs were obtained shortly after Visit 2 in 1,702 participants (64% women, 48% AA). Multilevel linear regression using generalized estimating equation estimated associations of adiposity (cross-sectional) or adiposity changes with WMH (accounting for intracranial size) or TBV adjusting for demographics, cardiovascular risk factors, and incorporating adiposity-by-race interactions. Adiposity-by-age interactions were examined.
resultsConcurrent TBV was inversely associated with BMI (β = -2.76 [95% confidence interval (CI): -4.99, -0.53]) and WC (β = -2.19 [CI: -4.04, -0.34]). Concurrent WMH were negatively associated with BMI (β = -0.04 [CI: -0.06, -0.01]) and, among NHW, with WC (β = -0.04 [CI: -0.06, -0.02]) but not with changes in BMI or WC. BMI increases were associated with lower TBV (β = -16.20, [CI: -30.34, -2.06]) in AA but not in NHW (β = -2.76 [CI: -14.02, 8.51]), although race-by-adiposity interactions were not supported. WC increases were not associated with MRI outcomes.
conclusionGreater measures of obesity and increases in measures of obesity, which are common in mid-life, could be detrimental to brain health, particularly in AA.
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