ArticleDevelopment (Cambridge, England)2017
The transcription factor mohawk homeobox regulates homeostasis of the periodontal ligament.
Article in Development (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Understanding Tendons: Lessons from Transgenic Mouse Models.Stem cells and development · 2018Pooled it
- Impact of mechanotransduction on gene expression changes in periodontal ligament during orthodontic tooth movement.Journal of bone and mineral metabolism · 2025Article
- Molecular basis of individual locomotor function: Integrated understanding of gene expression regulation in the development and homeostasis of the musculoskeletal system.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2025Review
- Unraveling the hidden complexity: Exploring dental tissues through single-cell transcriptional profiling.Regenerative therapy · 2024Review
- The Mohawk homeobox gene represents a marker and osteo-inhibitory factor in calvarial suture osteoprogenitor cells.Cell death & disease · 2024Article
- The essential role ofRegenerative therapy · 2024Article
- Multiomics analysis of cultured mouse periodontal ligament cell-derived extracellular matrix.Scientific reports · 2024Article
- Mechanisms of Osteoclastogenesis in Orthodontic Tooth Movement and Orthodontically Induced Tooth Root Resorption.Journal of bone metabolism · 2023Article
- Wnt/β-Catenin Signaling Inhibits Osteogenic Differentiation in Human Periodontal Ligament Fibroblasts.Biomimetics (Basel, Switzerland) · 2022Article
- Tendon-Specific Activation of Tenogenic Transcription Factors Enables Keeping Tenocytes' Identity In Vitro.International journal of molecular sciences · 2022Article
- Diverse stem cells for periodontal tissue formation and regeneration.Genesis (New York, N.Y. : 2000) · 2022Review
- Single Cell RNA Sequencing Reveals Critical Functions ofFrontiers in cell and developmental biology · 2022Article
- Hemocyte Clusters Defined by scRNA-Seq inFrontiers in immunology · 2022Article
- Mkx regulates the orthodontic tooth movement via osteoclast induction.Journal of bone and mineral metabolism · 2021Article
- PPARγ-Induced Global H3K27 Acetylation Maintains Osteo/Cementogenic Abilities of Periodontal Ligament Fibroblasts.International journal of molecular sciences · 2021Article
- Comparative Analysis of Tenogenic Gene Expression in Tenocyte-Derived Induced Pluripotent Stem Cells and Bone Marrow-Derived Mesenchymal Stem Cells in Response to Biochemical and Biomechanical Stimuli.Stem cells international · 2021Article
- Article
- Shedding new light on the mysteries of tooth eruption.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Autocrine regulation of mesenchymal progenitor cell fates orchestrates tooth eruption.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Essential role of Mohawk for tenogenic tissue homeostasis including spinal disc and periodontal ligament.Modern rheumatology · 2018Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
The periodontal ligament (PDL), which connects the teeth to the alveolar bone, is essential for periodontal tissue homeostasis. Although the significance of the PDL is recognized, molecular mechanisms underlying PDL function are not well known. We report that mohawk homeobox (Mkx), a tendon-specific transcription factor, regulates PDL homeostasis by preventing its degeneration. Mkx is expressed in the mouse PDL at the age of 10 weeks and expression remained at similar levels at 12 months. In Mkx
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.