Evidence map›Paper›PMID 27993974›Full record

ArticleInfection and immunity2017

The Transcriptional Regulator CpsY Is Important for Innate Immune Evasion in Streptococcus pyogenes.

Luis A Vega, Kayla M Valdes, Ganesh S Sundar, Ashton T Belew, Emrul Islam, Jacob Berge, Patrick Curry, Steven Chen, Najib M El-Sayed, Yoann Le Breton and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Luis A VegaDepartment of Cell Biology & Molecular Genetics and Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA.
Kayla M ValdesDepartment of Cell Biology & Molecular Genetics and Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA.
Ganesh S SundarDepartment of Cell Biology & Molecular Genetics and Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA.
Ashton T BelewDepartment of Cell Biology & Molecular Genetics and Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA.
Emrul IslamDepartment of Cell Biology & Molecular Genetics and Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA.
Jacob BergeDepartment of Cell Biology & Molecular Genetics and Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA.
Patrick CurryDepartment of Cell Biology & Molecular Genetics and Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA.
Steven ChenDepartment of Cell Biology & Molecular Genetics and Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA.
Najib M El-SayedDepartment of Cell Biology & Molecular Genetics and Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA.ORCID http://orcid.org/0000-0001-7970-3312
Yoann Le BretonDepartment of Cell Biology & Molecular Genetics and Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA lebreton@umd.edu kmciver@umd.edu.
Kevin S McIverDepartment of Cell Biology & Molecular Genetics and Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA lebreton@umd.edu kmciver@umd.edu.
University of Maryland, College Park · US

Funding

PRD-Containing Virulence Regulators of Pathogenic StreptococciR01AI047928 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI MCIVER, KEVIN S. · 2001 to 2023
$6.5M
Profiling the Leishmania-macrophage Host-pathogen InfectomeR01AI094773 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI EL-SAYED, NAJIB M, MOSSER, DAVID M · 2011 to 2014
$2.5M
NIAID NIH HHS R01 AI047928NIAID NIH HHS R01 AI094773
6 · The paper itself

Abstract

As an exclusively human pathogen,

Indexed as

Immunity, InnateAnimalsBacterial ProteinsDisease Models, AnimalHost-Pathogen InteractionsHumansMacrophagesMiceMicrobial ViabilityMutationNeutrophilsStreptococcal InfectionsStreptococcus pyogenesTranscription FactorsVirulenceBacterial ProteinsTranscription FactorsCpsYhuman-specific virulenceimmune evasionLysR family regulatorstranscriptional regulation

Identifiers

PMID27993974
PMCPMC5328483
OpenAlexW2565143989

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.