Evidence map›Paper›PMID 27993972›Full record

ArticleInfection and immunity2017

Differential Macrophage Polarization from Pneumocystis in Immunocompetent and Immunosuppressed Hosts: Potential Adjunctive Therapy during Pneumonia.

Vijayalakshmi Nandakumar, Deanne Hebrink, Paige Jenson, Theodore Kottom, Andrew H Limper

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 65 citations in OpenAlex.

  1. Review
  2. Article
  3. Strain-Dependent Protective Innate Immunity AgainstJournal of fungi (Basel, Switzerland) · 2026
    Article
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  7. Immune responses of different hosts toEuropean respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  8. Article
  9. Article
  10. Diphenyl pyridine intervention improvesFrontiers in genetics · 2025
    Article
  11. Article
  12. Protective innate immunity againstInfection and immunity · 2024
    Article
  13. Article
  14. mBio · 2024
    Article
  15. Article
  16. Article
  17. SAGE open medical case reports · 2024
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Vijayalakshmi NandakumarThoracic Diseases Research Unit, Department of Medicine, Mayo Clinic and Foundation, Rochester, Minnesota, USA.
Deanne HebrinkThoracic Diseases Research Unit, Department of Medicine, Mayo Clinic and Foundation, Rochester, Minnesota, USA.
Paige JensonThoracic Diseases Research Unit, Department of Medicine, Mayo Clinic and Foundation, Rochester, Minnesota, USA.
Theodore KottomThoracic Diseases Research Unit, Department of Medicine, Mayo Clinic and Foundation, Rochester, Minnesota, USA.
Andrew H LimperThoracic Diseases Research Unit, Department of Medicine, Mayo Clinic and Foundation, Rochester, Minnesota, USA limper.andrew@mayo.edu.
Mayo Clinic · US

Funding

Pneumocystis: Macrophage & Epithelial ActivationR01HL062150 · NHLBI · MAYO CLINIC ROCHESTER · PI ANDREW H LIMPER · 1998 to 2026
$9.2M
NHLBI NIH HHS R01 HL062150
6 · The paper itself

Abstract

We explored differential polarization of macrophages during infection using a rat model of

Indexed as

Immunocompromised HostAdoptive TransferAnimalsDectin-1Disease Models, AnimalFemaleGene Expression ProfilingGene Expression RegulationLectins, C-TypeMacrophage ActivationMacrophages, AlveolarMortalityPneumocystisPneumonia, PneumocystisRatsDectin-1Lectins, C-Typemacrophagespneumocystispneumoniapolarization

Identifiers

PMID27993972
PMCPMC5328482
OpenAlexW2562632042

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.