Evidence map›Paper›PMID 27993966›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2017

Characterization of an Abiraterone Ultraresponsive Phenotype in Castration-Resistant Prostate Cancer Patient-Derived Xenografts.

Hung-Ming Lam, Ryan McMullin, Holly M Nguyen, Ilsa Coleman, Michael Gormley, Roman Gulati, Lisha G Brown, Sarah K Holt, Weimin Li, Deborah S Ricci and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 30 citations in OpenAlex.

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  5. Functional inversion of circadian regulator REV-ERBα leads to tumorigenic gene reprogramming.Proceedings of the National Academy of Sciences of the United States of America · 2024
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  17. Contribution of Adrenal Glands to Intratumor Androgens and Growth of Castration-Resistant Prostate Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2019
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 2 countries.

Hung-Ming LamDepartment of Urology, University of Washington, Seattle, Washington.
Ryan McMullinLabConnect, Seattle, Washington.
Holly M NguyenDepartment of Urology, University of Washington, Seattle, Washington.
Ilsa ColemanFred Hutchinson Cancer Research Center, Seattle, Washington.
Michael GormleyJanssen Research and Development, Spring House, Pennsylvania.
Roman GulatiFred Hutchinson Cancer Research Center, Seattle, Washington.
Lisha G BrownDepartment of Urology, University of Washington, Seattle, Washington.
Sarah K HoltDepartment of Urology, University of Washington, Seattle, Washington.
Weimin LiJanssen Research and Development, Spring House, Pennsylvania.
Deborah S RicciJanssen Research and Development, Raritan, New Jersey.
Karin VerstraetenJanssen Research and Development, Beerse, Belgium.
Shibu ThomasJanssen Research and Development, Spring House, Pennsylvania.
Elahe A MostaghelFred Hutchinson Cancer Research Center, Seattle, Washington.
Peter S NelsonFred Hutchinson Cancer Research Center, Seattle, Washington.
Robert L VessellaDepartment of Urology, University of Washington, Seattle, Washington.
Eva CoreyDepartment of Urology, University of Washington, Seattle, Washington. ecorey@u.washington.edu.
Fred Hutch Cancer Center · USJanssen (Belgium) · BE

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
TRANSCRIPTOME AND PROTEOME STRATIFICATION OF PROSTATE ADENOCARCINOMA PHENOTYPESP50CA097186 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETER S NELSON · 2002 to 2026
$58.1M
Steroid Metabolism in Castration-Resistant Prostate CancerP01CA163227 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PETER S NELSON · 2013 to 2026
$25.0M
Exploring high-does testosterone as a potential treatment for abiraterone-resistant prostate cancerR21CA194798 · NCI · UNIVERSITY OF WASHINGTON · PI COREY, EVA · 2016 to 2017
$370k
NCI NIH HHS P01 CA163227NCI NIH HHS P30 CA015704NCI NIH HHS P50 CA097186NCI NIH HHS R21 CA194798
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Abiraterone AcetateAnimalsDrug Resistance, NeoplasmGene Expression Regulation, NeoplasticHumansMaleMiceNeoplasm ProteinsNF-kappa BProstatic Neoplasms, Castration-ResistantReceptors, AndrogenReceptors, GlucocorticoidSignal TransductionXenograft Model Antitumor AssaysAbiraterone AcetateNeoplasm ProteinsNF-kappa BReceptors, AndrogenReceptors, Glucocorticoid

Identifiers

PMID27993966
PMCPMC5413408
OpenAlexW2566167458

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.