Evidence map›Paper›PMID 27993954›Full record

ArticleHypertension (Dallas, Tex. : 1979)2017

Arterial Stiffness and Risk of Overall Heart Failure, Heart Failure With Preserved Ejection Fraction, and Heart Failure With Reduced Ejection Fraction: The Health ABC Study (Health, Aging, and Body Composition).

Ambarish Pandey, Hassan Khan, Anne B Newman, Edward G Lakatta, Daniel E Forman, Javed Butler, Jarett D Berry

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 77 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ambarish PandeyFrom the Division of Cardiology, Department of Internal Medicine (A.P., J.D.B.) and Department of Clinical Sciences (J.D.B.), University of Texas Southwestern Medical Center, Dallas; Department of Internal Medicine, Emory University School of Medicine, Atlanta, GA (H.K.); Department of Epidemiology, Graduate School of Public Health at University of Pittsburgh, PA (A.B.N.); Laboratory of Cardiovascular Science, Biomedical Research Center, National Institutes of Heath, National Institute of Aging, Baltimore, MD (E.G.L.); Section of Geriatric Cardiology, Divisions of Geriatrics and Cardiology, University of Pittsburgh School of Medicine, VA Pittsburgh Healthcare System, PA (D.E.F.); and Division of Cardiology, Department of Internal Medicine, Stony Brook University School of Medicine, New York, NY (J.B.).
Hassan KhanFrom the Division of Cardiology, Department of Internal Medicine (A.P., J.D.B.) and Department of Clinical Sciences (J.D.B.), University of Texas Southwestern Medical Center, Dallas; Department of Internal Medicine, Emory University School of Medicine, Atlanta, GA (H.K.); Department of Epidemiology, Graduate School of Public Health at University of Pittsburgh, PA (A.B.N.); Laboratory of Cardiovascular Science, Biomedical Research Center, National Institutes of Heath, National Institute of Aging, Baltimore, MD (E.G.L.); Section of Geriatric Cardiology, Divisions of Geriatrics and Cardiology, University of Pittsburgh School of Medicine, VA Pittsburgh Healthcare System, PA (D.E.F.); and Division of Cardiology, Department of Internal Medicine, Stony Brook University School of Medicine, New York, NY (J.B.).
Anne B NewmanFrom the Division of Cardiology, Department of Internal Medicine (A.P., J.D.B.) and Department of Clinical Sciences (J.D.B.), University of Texas Southwestern Medical Center, Dallas; Department of Internal Medicine, Emory University School of Medicine, Atlanta, GA (H.K.); Department of Epidemiology, Graduate School of Public Health at University of Pittsburgh, PA (A.B.N.); Laboratory of Cardiovascular Science, Biomedical Research Center, National Institutes of Heath, National Institute of Aging, Baltimore, MD (E.G.L.); Section of Geriatric Cardiology, Divisions of Geriatrics and Cardiology, University of Pittsburgh School of Medicine, VA Pittsburgh Healthcare System, PA (D.E.F.); and Division of Cardiology, Department of Internal Medicine, Stony Brook University School of Medicine, New York, NY (J.B.).
Edward G LakattaFrom the Division of Cardiology, Department of Internal Medicine (A.P., J.D.B.) and Department of Clinical Sciences (J.D.B.), University of Texas Southwestern Medical Center, Dallas; Department of Internal Medicine, Emory University School of Medicine, Atlanta, GA (H.K.); Department of Epidemiology, Graduate School of Public Health at University of Pittsburgh, PA (A.B.N.); Laboratory of Cardiovascular Science, Biomedical Research Center, National Institutes of Heath, National Institute of Aging, Baltimore, MD (E.G.L.); Section of Geriatric Cardiology, Divisions of Geriatrics and Cardiology, University of Pittsburgh School of Medicine, VA Pittsburgh Healthcare System, PA (D.E.F.); and Division of Cardiology, Department of Internal Medicine, Stony Brook University School of Medicine, New York, NY (J.B.).
Daniel E FormanFrom the Division of Cardiology, Department of Internal Medicine (A.P., J.D.B.) and Department of Clinical Sciences (J.D.B.), University of Texas Southwestern Medical Center, Dallas; Department of Internal Medicine, Emory University School of Medicine, Atlanta, GA (H.K.); Department of Epidemiology, Graduate School of Public Health at University of Pittsburgh, PA (A.B.N.); Laboratory of Cardiovascular Science, Biomedical Research Center, National Institutes of Heath, National Institute of Aging, Baltimore, MD (E.G.L.); Section of Geriatric Cardiology, Divisions of Geriatrics and Cardiology, University of Pittsburgh School of Medicine, VA Pittsburgh Healthcare System, PA (D.E.F.); and Division of Cardiology, Department of Internal Medicine, Stony Brook University School of Medicine, New York, NY (J.B.).
Javed ButlerFrom the Division of Cardiology, Department of Internal Medicine (A.P., J.D.B.) and Department of Clinical Sciences (J.D.B.), University of Texas Southwestern Medical Center, Dallas; Department of Internal Medicine, Emory University School of Medicine, Atlanta, GA (H.K.); Department of Epidemiology, Graduate School of Public Health at University of Pittsburgh, PA (A.B.N.); Laboratory of Cardiovascular Science, Biomedical Research Center, National Institutes of Heath, National Institute of Aging, Baltimore, MD (E.G.L.); Section of Geriatric Cardiology, Divisions of Geriatrics and Cardiology, University of Pittsburgh School of Medicine, VA Pittsburgh Healthcare System, PA (D.E.F.); and Division of Cardiology, Department of Internal Medicine, Stony Brook University School of Medicine, New York, NY (J.B.).
Jarett D BerryFrom the Division of Cardiology, Department of Internal Medicine (A.P., J.D.B.) and Department of Clinical Sciences (J.D.B.), University of Texas Southwestern Medical Center, Dallas; Department of Internal Medicine, Emory University School of Medicine, Atlanta, GA (H.K.); Department of Epidemiology, Graduate School of Public Health at University of Pittsburgh, PA (A.B.N.); Laboratory of Cardiovascular Science, Biomedical Research Center, National Institutes of Heath, National Institute of Aging, Baltimore, MD (E.G.L.); Section of Geriatric Cardiology, Divisions of Geriatrics and Cardiology, University of Pittsburgh School of Medicine, VA Pittsburgh Healthcare System, PA (D.E.F.); and Division of Cardiology, Department of Internal Medicine, Stony Brook University School of Medicine, New York, NY (J.B.). jarett.berry@utsouthwestern.edu.
Emory University · USUniversity of Pittsburgh · USVA Pittsburgh Healthcare System · US

Funding

VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6M
Health, Aging and Body Composition StudyZIAAG007390 · NIA · NATIONAL INSTITUTE ON AGING · PI LAUNER, LENORE J · 2009 to 2024
$4.0M
Peripheral Nerve Function Decline in an Aged CohortR01AG028050 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STROTMEYER, ELSA S. · 2007 to 2015
$3.5M
End of Life in the Very OldR01NR012459 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALBERT, STEVEN M, LUNNEY, JUNE R · 2011 to 2015
$2.7M
DYNAMICS OF HEALTH .AGING . AND BODY COMPOSITION /Pittsburgh/-260962101N01AG062101 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 1996 to 2004
$996k
DYNAMICS OF HEALTH . AGING . AND BODY COMPOSITION /Memphis/-26062103N01AG062103 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · 1996 to 2004
$793k
Health, Aging and Body Composition StudyZ01AG007390 · NIA · NATIONAL INSTITUTE ON AGING · PI HARRIS, TAMARA B. · 2006 to 2008
$738k
HEALTH ABC--COORDINATING UNIT /California/-260062106N01AG062106 · NIA · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · 1996 to 2004
$109k
Intramural NIH HHS Z01 AG007390Intramural NIH HHS ZIA AG007390NIA NIH HHS N01-AG-6-2101NIA NIH HHS N01-AG-6-2103NIA NIH HHS N01-AG-6-2106NIA NIH HHS P30 AG024827NIA NIH HHS R01 AG028050NINR NIH HHS R01 NR012459
6 · The paper itself

Abstract

Higher arterial stiffness is associated with increased risk of atherosclerotic events. However, its contribution toward risk of heart failure (HF) and its subtypes, HF with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF), independent of other risk factors is not well established. In this study, we included Health ABC study (Health, Aging, and Body Composition) participants without prevalent HF who had arterial stiffness measured as carotid-femoral pulse wave velocity (cf-PWV) at baseline (n=2290). Adjusted Cox-proportional hazards models were constructed to determine the association between continuous and data-derived categorical measures (tertiles) of cf-PWV and incidence of HF and its subtypes (HFpEF [ejection fraction >45%] and HFrEF [ejection fraction ≤45%]). We observed 390 HF events (162 HFpEF and 145 HFrEF events) over 11.4 years of follow-up. In adjusted analysis, higher cf-PWV was associated with greater risk of HF after adjustment for age, sex, ethnicity, mean arterial pressure, and heart rate (hazard ratio [95% confidence interval] for cf-PWV tertile 3 versus tertile 1 [ref] =1.35 [1.05-1.73]). However, this association was not significant after additional adjustment for other cardiovascular risk factors (hazard ratio [95% confidence interval], 1.14 [0.88-1.47]). cf-PWV velocity was also not associated with risk of HFpEF and HFrEF after adjustment for potential confounders (most adjusted hazard ratio [95% confidence interval] for cf-PWV tertile 3 versus tertile 1 [ref]: HFpEF, 1.06 [0.72-1.56]; HFrEF, 1.28 [0.83-1.97]). In conclusion, arterial stiffness, as measured by cf-PWV, is not independently associated with risk of HF or its subtypes after adjustment for traditional cardiovascular risk factors.

Indexed as

AgingForecastingHealth StatusAgedBody CompositionFemaleFollow-Up StudiesHeart FailureHumansIncidenceMalePrognosisProportional Hazards ModelsProspective StudiesPulse Wave AnalysisRisk Factorsarterial stiffnessejection fractionheart failurehypertensionpulse wave velocity

Identifiers

PMID27993954
PMCPMC5828168
OpenAlexW2581738455

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.